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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ripk3
receptor-interacting serine-threonine kinase 3
MGI:2154952
52 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Ripk3tm1Vmd/Ripk3+
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL 		embryonic lethality during organogenesis, complete penetrance J:182515
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Ripk3tm1Vmd/Ripk3tm1Vmd
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL 		lethality throughout fetal growth and development, complete penetrance J:182515
Casp8em1Hbz/Casp8em1Hbz
Ripk1em1Hbz/Ripk1em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased leukocyte cell number J:342732
decreased lymphocyte cell number J:342732
decreased mature B cell number J:342732
decreased T cell number J:342732
Casp8em1Hbz/Casp8em1Hbz
Ripk1em4Hbz/Ripk1em4Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased body size J:342732
preweaning lethality, complete penetrance J:342732
scaly skin J:342732
skin lesions J:342732
Casp8em1Hbz/Casp8em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased B cell number J:342732
decreased leukocyte cell number J:342732
decreased lymphocyte cell number J:342732
decreased mature B cell number J:342732
decreased T cell number J:342732
enlarged spleen J:342732
increased CD11b-high dendritic cell number J:342732
increased granulocyte number J:342732
increased macrophage cell number J:342732
Casp8tm1.1Raz/Casp8tm1.1Raz
Otulinem1Gvl/Otulinem1Gvl
Ripk3tm1Vmd/Ripk3tm1Vmd
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J 		normal embryo phenotype J:312394
enlarged lymph nodes J:312394
normal immune system phenotype J:312394
normal integument phenotype J:312394
Casp8tm1.1Raz/Casp8tm1.1Raz
Ripk3tm1Vmd/Ripk3+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal visceral yolk sac blood island morphology J:170815
abnormal vitelline vasculature morphology J:170815
embryonic growth arrest J:170815
embryonic lethality, complete penetrance J:170815
Casp8tm1.1Raz/Casp8tm1.1Raz
Ripk3tm1Vmd/Ripk3tm1Vmd
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal liver physiology J:170815
abnormal macrophage physiology J:170815
decreased hepatocyte apoptosis J:170814
decreased macrophage apoptosis J:170815
decreased thymocyte apoptosis J:170814
enlarged axillary lymph nodes J:170815
enlarged cervical lymph nodes J:170815
enlarged lymph nodes J:170814
enlarged spleen J:170814, J:170815
enlarged thymus J:170814
normal growth/size/body region phenotype J:170814
normal hematopoietic system phenotype J:170814, J:170815
normal immune system phenotype J:170815
increased B cell number J:170815
increased inflammatory response J:170815
increased leukocyte cell number J:170815
increased spleen white pulp amount J:170815
increased T cell number J:170814, J:170815
large lymphoid organs J:170814
lymph node hyperplasia J:170815
normal mortality/aging J:170814, J:170815
Casp8tm1.1Vmd/Casp8+
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6N 		lethality throughout fetal growth and development, complete penetrance J:209137
Casp8tm1.1Vmd/Casp8tm1.1Vmd
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6N 		enlarged lymph nodes J:209137
enlarged spleen J:209137
increased T cell number J:209137
normal mortality/aging J:209137
Cflartm1Ywh/Cflartm1Ywh
Gt(ROSA)26Sortm16(cre)Arte/Gt(ROSA)26Sor+
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac 		embryonic lethality prior to tooth bud stage J:209137
Csnk1g2em1Xidw/Csnk1g2em1Xidw
Ripk3tm1Xidw/Ripk3tm1Xidw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl 		normal homeostasis/metabolism phenotype J:298682
normal reproductive system phenotype J:298682
Cyldtm1Scs/Cyldtm1Scs
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		embryonic lethality prior to tooth bud stage J:209137
Faddtm1Mpa/Faddtm1Mpa
Ripk3tm1Vmd/Ripk3tm1Vmd
Tg(Vil1-cre)997Gum/0
B6.Cg-Faddtm1Mpa Ripk3tm1Vmd Tg(Vil1-cre)997Gum 		normal digestive/alimentary phenotype J:175865
normal mortality/aging J:175865
Mlkltm1.2Wsa/Mlkltm1.2Wsa
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6 * C57BL/6N 		embryonic lethality prior to tooth bud stage J:209137
Ppm1bGt(AW0406)Wtsi/Ppm1bGt(AW0406)Wtsi
Ripk3tm1Vmd/Ripk3tm1Vmd
B6.129-Ripk3tm1Vmd Ppm1bGt(AW0406)Wtsi 		normal cellular phenotype J:243815
Ripk1tm1.1Vmd/Ripk1+
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6N 		decreased hematopoietic cell number J:209137
decreased liver glycogen level J:209137
pallor J:209137
Ripk1tm1.1Vmd/Ripk1tm1.1Vmd
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6N 		abnormal intestine morphology J:209137
neonatal lethality J:209137
Ripk1tm1Geno/Ripk1tm1Geno
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6 * C57BL/6N 		embryonic lethality J:209137
Ripk3tm2Vmd/Ripk3tm2Vmd
Ticam1tm1Aki/Ticam1tm1Aki
involves: 129P2/OlaHsd * C57BL/6N 		embryonic lethality prior to tooth bud stage J:209137
Ripk3tm2Vmd/Ripk3tm2Vmd
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: C57BL/6 * C57BL/6N 		embryonic lethality prior to tooth bud stage J:209137
Ripk3tm2Vmd/Ripk3tm2Vmd
Tnfrsf25tm1Lex/Tnfrsf25tm1Lex
involves: 129S5/SvEvBrd * C57BL/6N 		embryonic lethality prior to tooth bud stage J:209137
Ripk3tm2Vmd/Ripk3tm2Vmd
Zbp1tm1Aki/Zbp1tm1Aki
involves: C57BL/6N 		embryonic lethality prior to tooth bud stage J:209137
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory