Gjc2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gjc2
gap junction protein, gamma 2
MGI:2153060

15 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gjc2^tm1(EGFP)Kwi/Gjc2^tm1(EGFP)Kwi involves: 129P2/OlaHsd * C57BL/6	abnormal brain morphology	J:83885
	abnormal cerebellum morphology	J:174197
	abnormal cerebellum white matter morphology	J:174197
	abnormal myelination	J:83885, J:174197
	abnormal oligodendrocyte physiology	J:174197
	astrocytosis	J:174197
	microgliosis	J:174197
	neurodegeneration	J:83885
Gjc2^tm1Paul/Gjc2^tm1Paul involves: 129/Sv * C57BL/6	no abnormal phenotype detected	J:84338
Gjc2^tm2.1Kwi/Gjc2⁺ involves: C57BL/6 * SJL	abnormal brain white matter morphology	J:174197
	abnormal cerebellum morphology	J:174197
	abnormal oligodendrocyte physiology	J:174197
	decreased locomotor activity	J:174197
	decreased vertical activity	J:174197
	increased oligodendrocyte number	J:174197
	microgliosis	J:174197
Gjc2^tm2.1Kwi/Gjc2^tm2.1Kwi involves: C57BL/6 * SJL	abnormal brain white matter morphology	J:174197
	abnormal cerebellum morphology	J:174197
	abnormal cerebellum white matter morphology	J:174197
	abnormal motor learning	J:174197
	abnormal myelination	J:174197
	abnormal oligodendrocyte physiology	J:174197
	astrocytosis	J:174197
	increased oligodendrocyte number	J:174197
	microgliosis	J:174197
	Purkinje cell degeneration	J:174197

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23