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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Dock2
dedicator of cyto-kinesis 2
MGI:2149010
40 phenotypes from 11 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Dock2m1Anu/Dock2m1Anu
C57BL/6JAnu-Dock2m1Anu
decreased B cell number J:104190
decreased T cell number J:104190
Dock2m1Btlr/Dock2m1Btlr
involves: C57BL/6J
abnormal B cell differentiation J:173592
abnormal class switch recombination J:185495
abnormal humoral immune response J:173592
decreased B cell number J:185495
decreased IgG level J:185495
decreased T cell number J:185495
normal immune system phenotype J:185495
Dock2m2Anu/Dock2m2Anu
C57BL/6JAnu-Dock2m2Anu
abnormal T cell morphology J:104190
decreased mature B cell number J:104190
decreased T cell number J:104190
Dock2m2Btlr/Dock2m2Btlr
C57BL/6J-Dock2m2Btlr
abnormal humoral immune response J:173670
decreased B cell number J:173670
decreased CD4-positive, alpha beta T cell number J:173670
decreased CD8-positive, alpha-beta T cell number J:173670
Dock2m2Btlr/Dock2m2Btlr
involves: C57BL/6J
abnormal B cell differentiation J:185495
abnormal class switch recombination J:185495
abnormal humoral immune response J:185495
decreased B cell number J:185495
decreased IgG level J:185495
decreased T cell number J:185495
normal immune system phenotype J:185495
Dock2m3Anu/Dock2m3Anu
C57BL/6NCrlAnu-Dock2m3Anu
abnormal CD4-positive, alpha beta T cell morphology J:104190
abnormal CD8-positive, alpha beta T cell morphology J:104190
decreased CD4-positive, alpha beta T cell number J:104190
Dock2m3Btlr/Dock2m3Btlr
C57BL/6J-Dock2m3Btlr
abnormal CD4-positive T cell differentiation J:191187
abnormal CD8-positive, alpha-beta T cell differentiation J:191187
abnormal humoral immune response J:191187
abnormal immune system physiology J:191187
decreased CD4-positive, alpha beta T cell number J:191187
decreased CD8-positive, alpha-beta T cell number J:191187
Dock2m4Btlr/Dock2m4Btlr
C57BL/6J-Dock2m4Btlr
abnormal B cell differentiation J:221486
abnormal CD4-positive T cell differentiation J:221486
abnormal CD8-positive, alpha-beta T cell differentiation J:221486
Dock2m5Btlr/Dock2+
C57BL/6J-Dock2m5Btlr
abnormal CD4-positive T cell differentiation J:225938
abnormal CD8-positive, alpha-beta T cell differentiation J:225938
decreased CD4-positive, alpha beta T cell number J:225938
decreased single-positive T cell number J:225938
impaired hematopoiesis J:225938
increased CD8-positive, alpha-beta T cell number J:225938
increased single-positive T cell number J:225938
Dock2m5Btlr/Dock2m5Btlr
C57BL/6J-Dock2m5Btlr
abnormal B cell differentiation J:225938
abnormal CD4-positive T cell differentiation J:225938
abnormal CD8-positive, alpha-beta T cell differentiation J:225938
decreased CD4-positive, alpha beta T cell number J:225938
decreased single-positive T cell number J:225938
impaired hematopoiesis J:225938
increased B cell number J:225938
increased CD8-positive, alpha-beta T cell number J:225938
increased single-positive T cell number J:225938
Dock2m6Btlr/Dock2m6Btlr
C57BL/6J-Dock2m6Btlr
decreased IgE level J:236689
decreased response to antigen J:236689
Dock2m7Btlr/Dock2+
C57BL/6J-Dock2m7Btlr
decreased B cell number J:255181
increased macrophage cell number J:255181
increased neutrophil cell number J:255181
Dock2m7Btlr/Dock2m7Btlr
C57BL/6J-Dock2m7Btlr
decreased B cell number J:255181
increased IgE level J:255181
increased macrophage cell number J:255181
increased neutrophil cell number J:255181
increased NK cell number J:255181
Dock2tm1Tsas/Dock2tm1Tsas
B6.Cg-Dock2tm1Tsas
abnormal cell migration J:130919
abnormal hematopoietic system morphology/development J:130919
decreased lymphocyte cell number J:130919
decreased mature B cell number J:130919
decreased T cell number J:130919
impaired neutrophil chemotaxis J:113266
increased sensitivity to xenobiotic induced morbidity/mortality J:130919
Dock2tm1Tsas/Dock2tm1Tsas
involves: C57BL/6
abnormal immune system morphology J:71005
abnormal leukocyte migration J:71005
abnormal Peyer's patch morphology J:71005
abnormal spleen morphology J:71005
abnormal spleen white pulp morphology J:71005
decreased marginal zone B cell number J:71005
lymph node hypoplasia J:71005
spleen hypoplasia J:71005

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory