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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lztfl1
leucine zipper transcription factor-like 1
MGI:1934860
54 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lztfl1tm1.1Zpl/Lztfl1tm1.1Zpl
involves: C57BL/6 * C57BL/6N 		malocclusion J:287261
obese J:287261
retina degeneration J:287261
vagina atresia J:287261
Lztfl1tm1.2Zpl/Lztfl1tm1.2Zpl
Tg(Adipoq-cre)1Evdr/0
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/NJ 		no abnormal phenotype detected J:287261
Lztfl1tm1.2Zpl/Lztfl1tm1.2Zpl
Tg(Camk2a-cre)#Stl/0
involves: 129S4/SvJaeSor * BALB/c * C57BL * C57BL/6 * C57BL/6N 		abnormal interlobular bile duct morphology J:287261
abnormal pancreas morphology J:287261
hepatic steatosis J:287261
impaired glucose tolerance J:287261
insulin resistance J:287261
obese J:287261
pancreatic islet hyperplasia J:287261
Lztfl1tm1.3Zpl/Lztfl1tm1.3Zpl
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N 		abnormal interlobular bile duct morphology J:287261
abnormal pancreas morphology J:287261
decreased birth body size J:287261
decreased body length J:287261
decreased embryonic cilium length J:287261
hepatic steatosis J:287261
impaired glucose tolerance J:287261
increased circulating glucose level J:287261
increased circulating leptin level J:287261
increased fat cell size J:287261
increased food intake J:287261
increased total body fat amount J:287261
insulin resistance J:287261
malocclusion J:287261
obese J:287261
pancreatic islet hyperplasia J:287261
photoreceptor outer segment degeneration J:287261
normal renal/urinary system phenotype J:287261
retina degeneration J:287261
retina photoreceptor degeneration J:287261
vagina atresia J:287261
Lztfl1tm1e(KOMP)Wtsi/Lztfl1tm1e(KOMP)Wtsi
involves: 129S/SvEv * C57BL/6N 		abnormal photoreceptor outer segment morphology J:226512
decreased a-wave amplitude J:226512
decreased b-wave amplitude J:226512
disorganized photoreceptor outer segment J:226512
enlarged brain ventricles J:226512
enlarged lateral ventricles J:226512
increased body weight J:226512
increased subcutaneous adipose tissue amount J:226512
increased susceptibility to age-related retinal degeneration J:226512
increased white adipose tissue amount J:226512
obese J:226512
retina cone cell degeneration J:226512
retina photoreceptor degeneration J:226512
retina rod cell degeneration J:226512
short photoreceptor outer segment J:226512
Lztfl1tm1e(KOMP)Wtsi/Lztfl1tm1e(KOMP)Wtsi
involves: C57BL/6N 		abnormal cauda epididymis morphology J:307611
abnormal seminiferous tubule epithelium morphology J:307611
abnormal sperm end piece morphology J:307611
abnormal sperm fibrous sheath morphology J:307611
abnormal sperm flagellum morphology J:307611
abnormal sperm flagellum thickness J:307611
abnormal sperm head morphology J:307611
abnormal sperm nucleus morphology J:307611
abnormal spermatid morphology J:307611
abnormal spermiogenesis J:307611
asthenozoospermia J:307611
decreased fertilization frequency J:307611
decreased litter size J:307611
oligozoospermia J:307611
reduced male fertility J:307611
short sperm flagellum J:307611
teratozoospermia J:307611
Lztfl1tm1Zpl/Lztfl1tm1Zpl
C57BL/6-Lztfl1tm1Zpl 		embryonic growth retardation J:287261
embryonic lethality during organogenesis, incomplete penetrance J:287261
malocclusion J:287261
obese J:287261
retina degeneration J:287261
vagina atresia J:287261
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory