Tlr9 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tlr9
toll-like receptor 9
MGI:1932389

25 phenotypes from 10 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tlr9^M1Btlr/Tlr9^M1Btlr involves: C57BL/6	abnormal cytokine secretion	J:88906
	abnormal macrophage physiology	J:88906
	abnormal NK cell physiology	J:88906
	abnormal NK T cell physiology	J:88906
	increased susceptibility to Herpesvirales infection	J:88906
	increased susceptibility to Herpesvirales infection induced morbidity/mortality	J:88906
Tlr9^M2Btlr/Tlr9⁺ C57BL/6J-Tlr9^M2Btlr	abnormal macrophage physiology	J:128405
Tlr9^M2Btlr/Tlr9^M2Btlr C57BL/6J-Tlr9^M2Btlr	abnormal macrophage physiology	J:128405
Tlr9^M2Btlr/Tlr9^M2Btlr C57BL/6J-Tlr9^M2Btlr	increased susceptibility to Herpesvirales infection	J:128405
Tlr9^m3Btlr/Tlr9^m3Btlr C57BL/6J-Tlr9^m3Btlr	abnormal macrophage physiology	J:128406
Tlr9^m3Btlr/Tlr9^m3Btlr C57BL/6J-Tlr9^m3Btlr	decreased B cell proliferation	J:128406
Tlr9^m4Btlr/Tlr9⁺ C57BL/6J-Tlr9^m4Btlr	abnormal macrophage physiology	J:132489
	abnormal plasmacytoid dendritic cell physiology	J:132489
	decreased B cell proliferation	J:132489
Tlr9^M5Btlr/Tlr9⁺ C57BL/6J-Tlr9^M5Btlr	decreased interferon-alpha secretion	J:147856
Tlr9^M5Btlr/Tlr9⁺ C57BL/6J-Tlr9^M5Btlr	decreased interferon-beta secretion	J:147856
Tlr9^M5Btlr/? C57BL/6J-Tlr9^M5Btlr	abnormal macrophage physiology	J:147856
Tlr9^M5Btlr/? C57BL/6J-Tlr9^M5Btlr	decreased tumor necrosis factor secretion	J:147856
Tlr9^m6Btlr/Tlr9^m6Btlr C57BL/6J-Tlr9^m6Btlr	increased susceptibility to induced colitis	J:155728
Tlr9^M7Btlr/Tlr9⁺ C57BL/6J-Tlr9^M7Btlr	decreased tumor necrosis factor secretion	J:165701
Tlr9^M7Btlr/Tlr9^M7Btlr C57BL/6J-Tlr9^M7Btlr	decreased tumor necrosis factor secretion	J:165701
Tlr9^M8Btlr/Tlr9^M8Btlr involves: C57BL/6J	decreased interferon-gamma secretion	J:168138
Tlr9^M9Btlr/Tlr9⁺ C57BL/6J-Tlr9^M9Btlr	decreased tumor necrosis factor secretion	J:220063
Tlr9^M9Btlr/Tlr9^M9Btlr C57BL/6J-Tlr9^M9Btlr	decreased tumor necrosis factor secretion	J:220063
Tlr9^tm1Aki/Tlr9^tm1Aki B6.129P2-Tlr9^tm1Aki	abnormal immune system physiology	J:121070
	abnormal response to infection	J:121070
	decreased interferon-alpha secretion	J:125611
	decreased interferon-beta secretion	J:125611
	decreased interleukin-12b secretion	J:118954, J:125611
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:105435
	decreased susceptibility to parasitic infection	J:116763
	decreased tumor necrosis factor secretion	J:121070
	impaired natural killer cell mediated cytotoxicity	J:125611
Tlr9^tm1Aki/Tlr9^tm1Aki involves: 129P2/OlaHsd	abnormal leukocyte migration	J:171379
Tlr9^tm1Aki/Tlr9^tm1Aki involves: 129P2/OlaHsd * BALB/c * C57BL/6	abnormal dendritic cell physiology	J:88244
Tlr9^tm1Aki/Tlr9^tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal B cell physiology	J:66049
	abnormal dendritic cell physiology	J:66049
	abnormal macrophage physiology	J:66049, J:117688
	abnormal T-helper 1 physiology	J:66049
	decreased inflammatory response	J:66049
	normal immune system phenotype	J:66049

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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