Cacng8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cacng8
calcium channel, voltage-dependent, gamma subunit 8
MGI:1932376

20 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cacng8^tm1.1Mwa/Cacng8^tm1.1Mwa involves: C57BL/6 * C57BL/6N * CBA	abnormal hippocampus pyramidal cell morphology	J:117149
Cacng8^tm1.1Suto/Cacng8^tm1.1Suto Not Specified	abnormal AMPA-mediated synaptic currents	J:179775
	abnormal excitatory postsynaptic currents	J:179775
	abnormal glutamate-mediated receptor currents	J:179775
	abnormal reproductive system physiology	J:179775
	normal mortality/aging	J:179775
	normal nervous system phenotype	J:179775
Cacng8^tm1Ran/Cacng8⁺ C57BL/6-Cacng8^tm1Ran	abnormal behavior	J:322011
	abnormal emotion/affect behavior	J:322011
	abnormal impulsive behavior control	J:322011
	abnormal nest building behavior	J:322011
	abnormal response to novel object	J:322011
	decreased miniature excitatory postsynaptic current amplitude	J:322011
	impaired active avoidance behavior	J:322011
	increased aggression	J:322011
	increased aggression towards mice	J:322011
	increased exploration in new environment	J:322011
Cacng8^tm1Ran/Cacng8^tm1Ran C57BL/6-Cacng8^tm1Ran	abnormal behavior	J:322011
	abnormal emotion/affect behavior	J:322011
	abnormal impulsive behavior control	J:322011
	abnormal nest building behavior	J:322011
	abnormal response to novel object	J:322011
	abnormal response to social novelty	J:322011
	decreased miniature excitatory postsynaptic current amplitude	J:322011
	impaired active avoidance behavior	J:322011
	increased aggression	J:322011
	increased aggression towards mice	J:322011
	increased exploration in new environment	J:322011
Cacng8^tm1Ran/Cacng8^tm1Ran involves: C57BL/6	abnormal synaptic transmission	J:102515
	decreased miniature excitatory postsynaptic current amplitude	J:197912
	reduced long-term potentiation	J:102515, J:179775

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23