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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dhx58
DExH-box helicase 58
MGI:1931560
24 phenotypes from 5 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dhx58em1(IMPC)J/Dhx58em1(IMPC)J
C57BL/6NJ-Dhx58em1(IMPC)J/Mmjax 		decreased prepulse inhibition J:211773
Dhx58tm1Aki/Dhx58tm1Aki
involves: 129/Sv * C57BL/6 		decreased circulating interferon-beta level J:156867
decreased interferon-beta secretion J:156867
decreased interleukin-6 secretion J:156867
enlarged uterus J:156867
increased susceptibility to Picornaviridae infection J:156867
increased susceptibility to Picornaviridae infection induced morbidity/mortality J:156867
prenatal lethality, incomplete penetrance J:156867
vagina atresia J:156867
Dhx58tm1Gnb/Dhx58tm1Gnb
involves: 129P2/OlaHsd * C57BL/6J 		abnormal interferon secretion J:146113
abnormal susceptibility to Riboviria infection J:146113
decreased interferon-alpha secretion J:146113
decreased interferon-beta secretion J:146113
decreased susceptibility to induced morbidity/mortality J:146113
decreased susceptibility to Riboviria infection J:146113
increased circulating interferon-gamma level J:146113
increased circulating interleukin-12 level J:146113
increased interferon-alpha secretion J:146113
increased interferon-beta secretion J:146113
increased susceptibility to induced morbidity/mortality J:146113
increased susceptibility to Picornaviridae infection J:146113
Dhx58tm1Itl/Dhx58tm1Itl
C57BL/6-Dhx58tm1Itl 		decreased interferon-beta secretion J:187386
decreased interferon-gamma secretion J:187386
decreased tumor necrosis factor secretion J:187386
increased susceptibility to Flaviviridae infection J:187386
increased susceptibility to Flaviviridae infection induced morbidity/mortality J:187386
increased T cell apoptosis J:187386
Dhx58tm2.1Aki/Dhx58tm2.1Aki
involves: 129/Sv * C57BL/6 		decreased interferon-beta secretion J:156867
decreased interleukin-6 secretion J:156867
increased susceptibility to Picornaviridae infection J:156867
increased susceptibility to Picornaviridae infection induced morbidity/mortality J:156867
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory