127 phenotypes from 18 alleles in 22 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Shank3em1(IMPC)H/Shank3em1(IMPC)H C57BL/6NTac-Shank3em1(IMPC)H/H	decreased circulating calcium level	J:211773
Shank3em1Hzo/Shank3em1Hzo involves: C57BL/6J	abnormal allogrooming behavior	J:305052
	abnormal miniature excitatory postsynaptic currents	J:305052
	abnormal social/conspecific interaction behavior	J:305052
	decreased dendritic spine density	J:305052
	decreased vocalization	J:305052
Shank3tm1.1Cya/Shank3+ B6.Cg-Shank3tm1.1Cya	abnormal vocalization	J:281328
	normal behavior/neurological phenotype	J:281328
	decreased stereotypic behavior	J:281328
	increased anxiety-related response	J:281328
	increased grooming behavior	J:281328
Shank3tm1.1Cya/Shank3tm1.1Cya B6.Cg-Shank3tm1.1Cya	abnormal brain wave pattern	J:281328
	abnormal nervous system electrophysiology	J:281328
	abnormal neuron physiology	J:281328
	normal behavior/neurological phenotype	J:281328
	decreased stereotypic behavior	J:281328
	decreased susceptibility to pharmacologically induced seizures	J:281328
	normal growth/size/body region phenotype	J:281328
	increased anxiety-related response	J:281328
	increased grooming behavior	J:281328
	increased miniature inhibitory postsynaptic current frequency	J:281328
	normal mortality/aging	J:281328
Shank3tm1.1Geno/Shank3tm1.1Geno involves: C57BL/6	abnormal response to novel object	J:293942
	abnormal response to novelty	J:293942
	skin lesions	J:186719
Shank3tm1.1Pfw/Shank3+ B6.129S6-Shank3tm1.1Pfw	abnormal glutamate-mediated receptor currents	J:198768
	abnormal long-term depression	J:198768
	abnormal social investigation	J:198768
	abnormal social/conspecific interaction behavior	J:198768
	abnormal vocalization	J:198768
	normal behavior/neurological phenotype	J:198768
	decreased startle reflex	J:198768
	decreased synaptic depression	J:198768
	increased aggression towards mice	J:198768
	induced hyperactivity	J:198768
	reduced long-term potentiation	J:198768
	reduced NMDA-mediated synaptic currents	J:198768
Shank3tm1.1Pfw/Shank3tm1.1Pfw B6.129S6-Shank3tm1.1Pfw	abnormal excitatory postsynaptic currents	J:204162
	abnormal glutamate-mediated receptor currents	J:204162
	abnormal innate avoidance response	J:204162
	abnormal miniature excitatory postsynaptic currents	J:204162
	abnormal motor coordination/balance	J:204162
	abnormal response to novel object	J:204162
	abnormal response to novelty	J:204162
	abnormal social investigation	J:204162
	abnormal spatial reference memory	J:204162
	normal behavior/neurological phenotype	J:204162
	decreased body weight	J:204162
	decreased exploration in new environment	J:204162
	decreased thermal nociceptive threshold	J:204162
	impaired coordination	J:204162
	impaired spatial learning	J:204162
	increased grooming behavior	J:204162
	normal nervous system phenotype	J:204162
	photophobia	J:204162
	reduced long-term potentiation	J:204162
Shank3tm1.2Bux/Shank3+ 129S6.B6(Cg)-Shank3tm1.2Bux	decreased anxiety-related response	J:206790
	impaired coordination	J:206790
	increased locomotor activity	J:206790
	increased thigmotaxis	J:206790
Shank3tm1.2Bux/Shank3+ B6N.Cg-Shank3tm1.2Bux	decreased locomotor activity	J:206790
Shank3tm1.2Bux/Shank3+ C57BL/6-Shank3tm1.2Bux	abnormal excitatory postsynaptic potential	J:175320
	abnormal miniature excitatory postsynaptic currents	J:175320
	abnormal neuron physiology	J:175320
	abnormal social investigation	J:175320
	decreased paired-pulse ratio	J:175320
	decreased vocalization	J:175320
	reduced long-term potentiation	J:175320
Shank3tm1.2Bux/Shank3tm1.2Bux 129S6.B6(Cg)-Shank3tm1.2Bux	abnormal conditioned emotional response	J:206790
	normal behavior/neurological phenotype	J:206790
	decreased anxiety-related response	J:206790
	decreased body weight	J:206790
	decreased grip strength	J:206790
	increased locomotor activity	J:206790
	lethality, incomplete penetrance	J:206790
Shank3tm1.2Bux/Shank3tm1.2Bux B6N.Cg-Shank3tm1.2Bux	abnormal response to novel object	J:206790
	decreased anxiety-related response	J:206790
	decreased body weight	J:206790
	decreased locomotor activity	J:206790
	decreased vertical activity	J:206790
	hyporesponsive to tactile stimuli	J:206790
	impaired coordination	J:206790
	lethality, incomplete penetrance	J:206790
Shank3tm1.2Bux/Shank3tm1.2Bux FVB.B6(Cg)-Shank3tm1.2Bux	abnormal response to novel object	J:206790
	normal behavior/neurological phenotype	J:206790
	decreased anxiety-related response	J:206790
	decreased body weight	J:206790
	increased vertical activity	J:206790
	lethality, incomplete penetrance	J:206790
Shank3tm1.2Yhj/Shank3tm1.2Yhj B6.129S7(C)-Shank3tm1.2Yhj	abnormal autopod morphology	J:235641
	abnormal basal ganglion morphology	J:235641
	abnormal behavior	J:235641
	abnormal brain commissure morphology	J:235641
	abnormal brain internal capsule morphology	J:235641
	abnormal brain white matter morphology	J:235641
	abnormal cerebellar peduncle morphology	J:235641
	abnormal cingulum morphology	J:235641
	abnormal dendritic spine morphology	J:235641
	abnormal ear development	J:235641
	abnormal nervous system electrophysiology	J:235641
	abnormal odor adaptation	J:235641
	abnormal olfactory lobe morphology	J:235641
	abnormal response to new environment	J:235641
	abnormal single cell response	J:235641
	abnormal social investigation	J:235641
	abnormal social/conspecific interaction behavior	J:235641
	abnormal spinal cord commissure morphology	J:235641
	abnormal synapse morphology	J:235641
	decreased amygdala size	J:235641
	decreased excitatory postsynaptic current frequency	J:235641
	decreased locomotor activity	J:235641
	decreased vocalization	J:235641
	enhanced contextual conditioning behavior	J:235641
	impaired coordination	J:235641
	impaired learning	J:235641
	impaired spatial learning	J:235641
	increased anxiety-related response	J:235641
	increased grooming behavior	J:235641
	increased startle reflex	J:235641
	normal nervous system phenotype	J:235641
	reduced long-term depression	J:235641
	skin lesions	J:235641
	small hippocampus	J:235641
	thalamus hyperplasia	J:235641
Shank3tm1.2Yhj/Shank3tm1.2Yhj involves: 129S7/SvEvBrd * C57BL/6J	increased grooming behavior	J:235641
	skin lesions	J:235641
Shank3tm1Cmpl/Shank3tm1Cmpl B6J.129S6-Shank3tm1Cmpl	abnormal CNS synaptic transmission	J:224381
	abnormal excitatory postsynaptic potential	J:224381
	abnormal long-term depression	J:224381
	abnormal miniature excitatory postsynaptic currents	J:224381
	abnormal motor learning	J:224381
	abnormal response to novel object	J:224381
	decreased body weight	J:224381
	decreased exploration in new environment	J:224381
	decreased post-tetanic potentiation	J:224381
	impaired coordination	J:224381
	impaired spatial learning	J:224381
	impaired synaptic plasticity	J:224381
Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp involves: C57BL/6N	abnormal CNS synaptic transmission	J:233405
	abnormal excitatory postsynaptic potential	J:233405
	abnormal miniature inhibitory postsynaptic current frequency	J:233405
	abnormal response to novelty	J:233405
	normal behavior/neurological phenotype	J:233405
	impaired spatial learning	J:233405
	increased vertical activity	J:233405
Shank3tm1Gfng/Shank3tm1Gfng involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal behavior/neurological phenotype	J:171113
	normal integument phenotype	J:171113
Shank3tm1Yhj/Shank3tm1Yhj B6.129S7-Shank3tm1Yhj	abnormal dendritic spine morphology	J:173402
	abnormal gait	J:173402
	abnormal long-term object recognition memory	J:173402
	abnormal motor capabilities/coordination/movement	J:173402
	abnormal motor learning	J:173402
	abnormal object recognition memory	J:173402
	abnormal social investigation	J:173402
	abnormal spatial learning	J:173402
	abnormal vocalization	J:173402
	normal behavior/neurological phenotype	J:173402
	decreased locomotor activity	J:173402
	decreased post-tetanic potentiation	J:173402
	decreased vertical activity	J:173402
	impaired coordination	J:173402
	impaired righting response	J:173402
	impaired synaptic plasticity	J:173402
	increased body weight	J:173402
	increased grooming behavior	J:173402
	increased stereotypic behavior	J:173402
	normal nervous system phenotype	J:173402
	reduced long-term potentiation	J:173402
	normal taste/olfaction phenotype	J:173402
Shank3tm2.1Bux/Shank3+ B6(Cg)-Shank3tm2.1Bux	abnormal nest building behavior	J:270363
	decreased locomotor activity	J:270363
	decreased startle reflex	J:270363
	decreased vocalization	J:270363
	impaired coordination	J:270363
	premature suckling reflex loss	J:270363
Shank3tm2.1Bux/Shank3tm2.1Bux B6(Cg)-Shank3tm2.1Bux	abnormal habituation to a novel odor	J:270363
	abnormal impulsive behavior control	J:270363
	abnormal locomotor activation	J:270363
	abnormal nest building behavior	J:270363
	abnormal reflex	J:270363
	abnormal response to novel object	J:270363
	abnormal righting response	J:270363
	abnormal sexual interaction	J:270363
	circling	J:270363
	decreased locomotor activity	J:270363
	decreased prepulse inhibition	J:270363
	decreased startle reflex	J:270363
	decreased vertical activity	J:270363
	decreased vocalization	J:270363
	enhanced cued conditioning behavior	J:270363
	hyperactivity	J:270363
	impaired contextual conditioning behavior	J:270363
	impaired coordination	J:270363
	impaired spatial learning	J:270363
	increased anxiety-related response	J:270363
	increased fear-related response	J:270363
	increased grooming behavior	J:270363
	long stride length	J:270363
	neonatal lethality, incomplete penetrance	J:270363
	postnatal growth retardation	J:270363
	premature death	J:270363
	premature suckling reflex loss	J:270363
	weakness	J:270363
Shank3tm2Cmpl/Shank3+ B6.129S6-Shank3tm2Cmpl	abnormal motor learning	J:289874
	abnormal response to social novelty	J:289874
	abnormal social investigation	J:289874
	abnormal social recognition	J:289874
	decreased anxiety-related response	J:289874
	decreased vertical activity	J:289874
	impaired coordination	J:289874
	increased grooming behavior	J:289874
	reduced long-term potentiation	J:289874
Shank3tm2Cmpl/Shank3tm2Cmpl B6.129S6-Shank3tm2Cmpl	abnormal response to social novelty	J:289874
	abnormal social investigation	J:289874
	abnormal social recognition	J:289874
	abnormal spatial reference memory	J:289874
	abnormal synaptic transmission	J:289874
	decreased anxiety-related response	J:289874
	decreased vertical activity	J:289874
	impaired coordination	J:289874
	impaired spatial learning	J:289874
	impaired synaptic plasticity	J:289874
	increased grooming behavior	J:289874
	reduced long-term potentiation	J:289874
Shank3tm2Gfng/Shank3+ B6.129-Shank3tm2Gfng/J	impaired discrimination learning	J:243083
Shank3tm2Gfng/Shank3tm2Gfng B6.129-Shank3tm2Gfng/J	abnormal learning/memory/conditioning	J:243083
	decreased locomotor activity	J:243083
Shank3tm2Gfng/Shank3tm2Gfng involves: 129S1/Sv * 129X1/SvJ	abnormal dendritic mushroom spine morphology	J:305052
	abnormal dendritic thin spine morphology	J:305052
	abnormal miniature excitatory postsynaptic currents	J:305052
	abnormal postsynaptic density morphology	J:305052
Shank3tm2Gfng/Shank3tm2Gfng involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal medium spiny neuron morphology	J:171113
	abnormal miniature excitatory postsynaptic currents	J:171113
	abnormal postsynaptic density morphology	J:171113
	abnormal striatum morphology	J:171113
	normal behavior/neurological phenotype	J:171113
	decreased vertical activity	J:171113
	environmentally induced seizures	J:171113
	increased anxiety-related response	J:171113
	increased grooming behavior	J:171113
	skin lesions	J:171113
	social withdrawal	J:171113
Shank3tm3.1Gfng/Shank3+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal allogrooming behavior	J:230887
	abnormal miniature excitatory postsynaptic currents	J:230887
	decreased exploration in new environment	J:230887
	increased anxiety-related response	J:230887
Shank3tm3.1Gfng/Shank3tm3.1Gfng involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal dendritic spine morphology	J:230887
	abnormal miniature excitatory postsynaptic currents	J:230887
	abnormal motor learning	J:230887
	abnormal paired-pulse inhibition	J:230887
	abnormal social investigation	J:230887
	abnormal social/conspecific interaction behavior	J:230887
	abnormal startle reflex	J:230887
	decreased excitatory postsynaptic current amplitude	J:230887
	decreased exploration in new environment	J:230887
	decreased locomotor activity	J:230887
	impaired coordination	J:230887
	increased aggression towards mice	J:230887
	increased anxiety-related response	J:230887
	increased grooming behavior	J:230887
	reduced NMDA-mediated synaptic currents	J:230887
Shank3tm3.2Cmpl/Shank3+ B6.129S6(Cg)-Shank3tm3.2Cmpl	abnormal object recognition memory	J:289884
	abnormal synaptic transmission	J:289884
	excessive vocalization	J:289884
	impaired spatial learning	J:289884
	increased grooming behavior	J:289884
Shank3tm3.2Cmpl/Shank3tm3.2Cmpl B6.129S6(Cg)-Shank3tm3.2Cmpl	abnormal object recognition memory	J:289884
	abnormal social investigation	J:289884
	abnormal synaptic transmission	J:289884
	normal behavior/neurological phenotype	J:289884
	excessive vocalization	J:289884
	impaired spatial learning	J:289884
	impaired synaptic plasticity	J:289884
	increased grooming behavior	J:289884
	increased thigmotaxis	J:289884
	reduced long-term potentiation	J:289884
Shank3tm4.1Gfng/Shank3+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal dendritic spine morphology	J:230887
	abnormal miniature excitatory postsynaptic currents	J:230887
	abnormal social investigation	J:230887
	increased anxiety-related response	J:230887
Shank3tm4.1Gfng/Shank3tm4.1Gfng involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal dendritic spine morphology	J:230887
	abnormal miniature excitatory postsynaptic currents	J:230887
	abnormal motor learning	J:230887
	abnormal paired-pulse inhibition	J:230887
	abnormal social investigation	J:230887
	abnormal startle reflex	J:230887
	decreased excitatory postsynaptic current amplitude	J:230887
	decreased exploration in new environment	J:230887
	decreased locomotor activity	J:230887
	impaired coordination	J:230887
	increased aggression towards mice	J:230887
	increased anxiety-related response	J:230887
	increased grooming behavior	J:230887
	reduced NMDA-mediated synaptic currents	J:230887
Shank3tm5.1Gfng/Shank3tm5.1Gfng involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J	decreased excitatory postsynaptic current amplitude	J:229668
	decreased exploration in new environment	J:229668
	impaired coordination	J:229668
	increased anxiety-related response	J:229668
	increased grooming behavior	J:229668
Shank3tm5.1Gfng/Shank3tm5.1Gfng Tg(CAG-cre/Esr1*)1Lbe/0 involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J	abnormal dendritic spine morphology	J:229668
	abnormal medium spiny neuron morphology	J:229668
	abnormal miniature excitatory postsynaptic currents	J:229668
	abnormal social investigation	J:229668
	decreased body weight	J:229668
	decreased excitatory postsynaptic current amplitude	J:229668
	decreased exploration in new environment	J:229668
	decreased vertical activity	J:229668
	impaired coordination	J:229668
	increased anxiety-related response	J:229668
	increased grooming behavior	J:229668