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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cacna2d2
calcium channel, voltage-dependent, alpha 2/delta subunit 2
MGI:1929813
44 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Cacna2d2du/Cacna2d2du
involves: C3H * DBA/2J
abnormal miniature endplate potential J:121463
abnormal motor neuron morphology J:121463
abnormal neuromuscular synapse morphology J:121463
decreased body weight J:121463
decreased neurotransmitter release J:121463
Cacna2d2du/Cacna2d2du
involves: DBA/2J
abnormal gait J:116
decreased body size J:116
decreased survivor rate J:116
reduced female fertility J:116
reduced male fertility J:116
Cacna2d2du/Cacna2d2du
TKDU
abnormal CNS glial cell morphology J:152373
abnormal dorsal spinal root morphology J:152373
abnormal gait J:152373
abnormal glial cell physiology J:152373
abnormal hindbrain development J:152373
abnormal hindbrain morphology J:152373
abnormal medulla oblongata morphology J:152373
abnormal myelination J:152373
abnormal neuron morphology J:152373
abnormal Purkinje cell morphology J:152373
abnormal spinal cord morphology J:152373
abnormal spinal nerve morphology J:152373
abnormal stationary movement J:152373
abnormal ventral spinal root morphology J:152373
abnormal vertebral column morphology J:152373
ataxia J:152373
axonal dystrophy J:152373
decreased body size J:152373
decreased neuron number J:152373
decreased pons size J:152373
decreased Purkinje cell number J:152373
decreased spinal cord size J:152373
hindlimb paralysis J:152373
induced hyperactivity J:152373
premature death J:152373
Purkinje cell degeneration J:152373
seizures J:152373
short vertebral body J:152373
skeletal muscle hypoplasia J:152373
small cerebellum J:152373
Cacna2d2du/Cacna2d2du
TKDU/DnJ
abnormal enzyme/coenzyme activity J:5175
abnormal myelination J:5263
abnormal spinal cord white matter morphology J:43719
decreased brain weight J:5263
normal endocrine/exocrine gland phenotype J:5263
induced hyperactivity J:5263
normal nervous system phenotype J:43719, J:70845
postnatal growth retardation J:5263
seizures J:5263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory