Tsc1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tsc1
TSC complex subunit 1
MGI:1929183

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda Tsc1^tm1.1Djk/Tsc1⁺ involves: 129S4/SvJae * C57BL/6	decreased body size	J:199720
	neonatal lethality, incomplete penetrance	J:199720
Lin28b^tm1.1Gqda/Lin28b^tm1.1Gqda Tsc1^tm1.1Djk/Tsc1⁺ involves: 129S4/SvJae * C57BL/6 * FVB	normal growth/size/body region phenotype	J:199720
Lin28b^tm1Gqda/Lin28b^tm1Gqda Myf5^tm1(cre)Mrc/Myf5⁺ Tsc1^tm1Djk/Tsc1⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	normal growth/size/body region phenotype	J:199720
Nf1^tm1Fcr/Nf1⁺ Tsc1^tm1Djk/Tsc1^tm1Djk Tg(GFAP-cre)#Gtm/0 involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA	normal neoplasm	J:176586
	premature death	J:176586
Pdpk1^tm1Maka/Pdpk1^tm1Maka Tsc1^tm1Djk/Tsc1^tm1Djk Tg(Gdf9-icre)5092Coo/? involves: 129S4/SvJae * C57BL/6J	abnormal ovarian follicle morphology	J:155357
Pten^tm1Hwu/Pten^tm1Hwu Tsc1^tm1Djk/Tsc1^tm1Djk Tg(Gdf9-icre)5092Coo/? involves: 129S4/SvJae * C57BL/6J	abnormal ovarian follicle morphology	J:155357
Rheb^tm1.1Yelg/Rheb⁺ Tsc1^tm1Chdl/Tsc1^tm1Chdl B6.129P2-Tsc1^tm1Chdl Rheb^tm1.1Yelg	decreased fetal size	J:170999
	fetal growth retardation	J:170999
	increased embryonic tissue cell apoptosis	J:170999
	lethality throughout fetal growth and development, complete penetrance	J:170999
Slc38a1^tm1.1Ttaka/Slc38a1^tm1.1Ttaka Tsc1^tm1Djk/Tsc1⁺ Tg(Syn1-cre)671Jxm/0 involves: 129S4/SvJae * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj	normal nervous system phenotype	J:288818
Trp53^tm1Brn/Trp53^tm1Brn Tsc1^tm1Djk/Tsc1^tm1Djk involves: 129P2/OlaHsd * 129S4/SvJae	hemorrhagic ascites	J:212578
	increased mesothelioma incidence	J:212578
	premature death	J:212578
Tsc1^tm1Djk/Tsc1^tm1Djk Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae * 129S4/SvJaeSor	abnormal brain morphology	J:221022
	abnormal brain ventricle morphology	J:221022
	abnormal neuron morphology	J:221022
	abnormal postnatal subventricular zone morphology	J:221022
	cachexia	J:221022
	enlarged lateral ventricles	J:221022
	hunched posture	J:221022
	hydrocephaly	J:221022
	increased brain size	J:221022
	premature death	J:221022

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23