68 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Htra2mnd2/Htra2mnd2 B6.Cg-Htra2mnd2	abnormal astrocyte morphology	J:76481
	abnormal brain morphology	J:76481
	abnormal interleukin level	J:76481
	abnormal tumor necrosis factor level	J:76481
	akinesia	J:76481
	bradykinesia	J:76481
	dystonia	J:76481
	gliosis	J:76481
	impaired balance	J:76481
	increased stereotypic behavior	J:76481
	motor neuron degeneration	J:76481
	muscle spasm	J:76481
	neurodegeneration	J:76481
	postnatal growth retardation	J:76481
Htra2mnd2/Htra2mnd2 involves: C3H/He * C57BL/6J	abnormal gait	J:12780
	decreased locomotor activity	J:12780
	dystrophic muscle	J:12780
	hunched posture	J:12780
	impaired balance	J:12780
	postnatal growth retardation	J:12780
	premature death	J:12780
Htra2mnd2/Htra2mnd2 involves: C3H/HeJ * C57BL/6J * CAST/Ei	abnormal action potential	J:12780
	abnormal gait	J:50420
	abnormal spinal cord morphology	J:12780
	abnormal thymus morphology	J:12780
	decreased total body fat amount	J:50420
	hunched posture	J:50420
	impaired balance	J:50420
	muscular atrophy	J:50420
	postnatal growth retardation	J:50420
	premature death	J:12780
	seizures	J:50420
	spleen atrophy	J:12780
Htra2mnd2/Htra2mnd2 involves: C57BL/6J	abnormal behavior	J:132627
	abnormal bone marrow cell morphology/development	J:132627
	abnormal immune system morphology	J:132627
	abnormal nervous system morphology	J:132627
	decreased double-positive T cell number	J:132627
	decreased pre-B cell number	J:132627
	decreased pro-B cell number	J:132627
	decreased single-positive T cell number	J:132627
Htra2tm1.1(KOMP)Vlcg/Htra2tm1.1(KOMP)Vlcg C57BL/6N-Htra2tm1.1(KOMP)Vlcg/Ucd	preweaning lethality, incomplete penetrance	J:211773
Htra2tm1.1Hohj/Htra2tm1.1Hohj Tg(Nes-cre)1Kln/0 involves: C57BL/6J	abnormal mitochondrial morphology	J:225666
	abnormal respiratory electron transport chain	J:225666
	ataxia	J:225666
	decreased body weight	J:225666
	decreased grip strength	J:225666
	impaired balance	J:225666
	increased brain apoptosis	J:225666
	lethargy	J:225666
	muscle weakness	J:225666
	normal nervous system phenotype	J:225666
	no spontaneous movement	J:225666
	paralysis	J:225666
	postnatal growth retardation	J:225666
	premature death	J:225666
	spleen atrophy	J:225666
	thymus atrophy	J:225666
	tremors	J:225666
Htra2tm1.2Hohj/Htra2tm1.2Hohj involves: C57BL/6 * C57BL/6J	abnormal cerebellar granule cell morphology	J:225666
	abnormal mitochondrial crista morphology	J:225666
	abnormal mitochondrial inner membrane morphology	J:225666
	abnormal mitochondrial morphology	J:225666
	abnormal respiratory electron transport chain	J:225666
	ataxia	J:225666
	decreased body weight	J:225666
	decreased grip strength	J:225666
	decreased locomotor activity	J:225666
	decreased lymphocyte cell number	J:225666
	dilated mitochondrion	J:225666
	impaired balance	J:225666
	impaired coordination	J:225666
	increased brain apoptosis	J:225666
	lethargy	J:225666
	muscle weakness	J:225666
	no spontaneous movement	J:225666
	paralysis	J:225666
	postnatal growth retardation	J:225666
	premature death	J:225666
	spleen atrophy	J:225666
	thymus atrophy	J:225666
	tremors	J:225666
Htra2tm1Jdo/Htra2tm1Jdo involves: 129P/Ola * C57BL/6	abnormal basal ganglion morphology	J:94227
	abnormal locomotor behavior	J:94227
	abnormal mitochondrial morphology	J:94227
	abnormal stationary movement	J:94227
	akinesia	J:94227
	decreased body size	J:94227
	decreased body weight	J:94227
	decreased brain size	J:94227
	decreased brain weight	J:94227
	decreased locomotor activity	J:94227
	hunched posture	J:94227
	impaired coordination	J:94227
	increased apoptosis	J:94227
	increased susceptibility to neuronal excitotoxicity	J:94227
	limb grasping	J:94227
	loss of basal ganglia neurons	J:94227
	premature death	J:94227
	small heart	J:94227
	small spleen	J:94227
	small thymus	J:94227
	sparse hair	J:94227
	tremors	J:94227