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Mammalian Phenotype Ontology Annotations
Query Results - Summary
mechanistic target of rapamycin kinase
135 phenotypes from 14 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
involves: C57BL/6JAnu
decreased body size J:207898
decreased CD4-positive, alpha beta T cell number J:207898
decreased splenocyte number J:207898
normal immune system phenotype J:207898
involves: BTBR/J * C57BL/6J
abnormal diencephalon morphology J:53291
abnormal embryonic neuroepithelium morphology J:53291
abnormal forebrain morphology J:53291
abnormal midbrain morphology J:53291
absent embryonic telencephalon J:53291
decreased embryo size J:53291
embryonic growth retardation J:53291
embryonic lethality, complete penetrance J:53291
forebrain hypoplasia J:53291
incomplete embryo turning J:53291
Not Specified
abnormal embryonic tissue morphology J:94381
absent embryonic telencephalon J:94381
decreased embryo size J:94381
embryonic growth arrest J:94381
embryonic growth retardation J:94381
incomplete embryo turning J:94381
involves: 129S5/SvEvBrd
abnormal trophoblast giant cell morphology J:137592
absent inner cell mass proliferation J:137592
involves: BALB/c * C57BL/6J
abnormal muscle physiology J:162945
decreased circulating insulin-like growth factor I level J:162945
decreased lean body mass J:162945
decreased skeletal muscle weight J:162945
increased total body fat amount J:162945
involves: BALB/c * C57BL/6J
embryonic lethality J:162945
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
abnormal autophagy J:163763
abnormal mitochondrial physiology J:163763
abnormal myocardial fiber morphology J:163763
abnormal myocardial fiber physiology J:163763
abnormal sarcomere morphology J:163763
abnormal translation J:163763
ascites J:163763
cardiac interstitial fibrosis J:163763
congestive heart failure J:163763
decreased cardiac muscle contractility J:163763
decreased ventricle muscle contractility J:163763
dilated cardiomyopathy J:163763
dilated mitochondria J:163763
enlarged heart J:163763
enlarged heart atrium J:163763
increased cardiomyocyte apoptosis J:163763
increased heart ventricle size J:163763
increased response of heart to induced stress J:163763
pleural effusion J:163763
premature death J:163763
small myocardial fiber J:163763
thin interventricular septum J:163763
thin ventricular wall J:163763
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)
no abnormal phenotype detected J:94133
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)
abnormal developmental patterning J:94133
abnormal embryonic tissue morphology J:94133
abnormal extraembryonic tissue morphology J:94133
abnormal trophoblast layer morphology J:94133
embryonic growth arrest J:94133
embryonic growth retardation J:94133
embryonic lethality during organogenesis, complete penetrance J:94133
inner cell mass degeneration J:94133
small ectoplacental cone J:94133
involves: 129S1/Sv * C57BL/6
normal growth/size/body region phenotype J:168600
normal immune system phenotype J:168600
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
abnormal cell morphology J:184667
abnormal podocyte morphology J:184667
abnormal renal glomerular capsule morphology J:184667
abnormal renal glomerulus morphology J:184667
abnormal renal tubule morphology J:184667
abnormal urine homeostasis J:184667
increased glomerular capsule space J:184667
podocyte foot process effacement J:184667
postnatal growth retardation J:184667
involves: 129S4/SvJae * C57BL/6J * SJL
abnormal diaphragm morphology J:162918
abnormal gastrocnemius morphology J:162918
abnormal hypaxial muscle morphology J:162918
abnormal limb posture J:162918
abnormal muscle contractility J:162918
abnormal muscle morphology J:162918
abnormal muscle physiology J:162918
abnormal muscle relaxation J:162918
abnormal oxygen consumption J:162918
abnormal respiration J:162918
abnormal skeletal muscle fiber morphology J:162918
abnormal soleus morphology J:162918
abnormal tibialis anterior morphology J:162918
centrally nucleated skeletal muscle fibers J:162918
decreased body weight J:162918
decreased circulating glucose level J:162918
decreased mitochondria number J:162918
decreased oxygen consumption J:162918
increased skeletal muscle glycogen level J:162918
kyphosis J:162918
muscle fatigue J:162918
postnatal growth retardation J:162918
premature death J:162918
skeletal muscle degeneration J:162918
skeletal muscle fiber degeneration J:162918
involves: 129S4/SvJae * C57BL/6 * DBA/2
abnormal T cell differentiation J:150108
abnormal T cell subpopulation ratio J:150108
abnormal thymus cell ratio J:150108
decreased interferon-gamma secretion J:150108
decreased interleukin-2 secretion J:150108
decreased interleukin-17 secretion J:150108
decreased T cell proliferation J:150108
decreased tumor necrosis factor secretion J:150108
increased regulatory T cell number J:150108
involves: C57BL/6 * SJL
prenatal lethality, complete penetrance J:184667
decreased blood urea nitrogen level J:175295
decreased circulating LDL cholesterol level J:175295
increased circulating LDL cholesterol level J:175295
increased mean corpuscular hemoglobin J:175295
preweaning lethality, complete penetrance J:211773
involves: 129S4/SvJae * C57BL/6
abnormal axolemma morphology J:181341
abnormal axon morphology J:181341
abnormal internode morphology J:181341
abnormal motor coordination/balance J:181341
abnormal myelin sheath morphology J:181341
abnormal myelination J:181341
abnormal Schwann cell morphology J:181341
decreased nerve conduction velocity J:181341
decreased Schwann cell number J:181341
involves: 129S1/Sv * C57BL/6
abnormal B cell differentiation J:168600
abnormal B cell physiology J:168600
abnormal humoral immune response J:168600
abnormal T cell morphology J:168600
abnormal T cell physiology J:168600
decreased B cell number J:168600
decreased B cell proliferation J:168600
decreased body size J:168600
decreased body weight J:168600
decreased double-positive T cell number J:168600
decreased follicular B cell number J:168600
decreased IgG level J:168600
decreased IgM level J:168600
decreased marginal zone B cell number J:168600
decreased monocyte cell number J:168600
decreased neutrophil cell number J:168600
decreased plasma cell number J:168600
decreased splenocyte apoptosis J:168600
decreased splenocyte proliferation J:168600
decreased thymocyte number J:168600
decreased transitional stage T1 B cell number J:168600
increased CD4-positive, alpha beta T cell number J:168600
increased CD8-positive, alpha-beta T cell number J:168600
preweaning lethality, incomplete penetrance J:168600
small spleen J:168600
involves: 129S4/SvJae
abnormal gastrulation J:92252
abnormal trophoblast layer morphology J:92252
absent inner cell mass proliferation J:92252
embryonic lethality between implantation and somite formation, complete penetrance J:92252

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory