Sirt2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sirt2
sirtuin 2
MGI:1927664

28 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sirt2^tm1.1Auw/Sirt2^tm1.1Auw involves: 129 * C57BL/6J	no abnormal phenotype detected	J:177468
Sirt2^tm1.1Auw/Sirt2^tm1.1Auw Tg(Mpz-cre)26Mes/0 involves: 129 * C57BL/6J * FVB/N	abnormal myelination	J:177468
	abnormal response to injury	J:177468
	normal behavior/neurological phenotype	J:177468
	decreased nerve conduction velocity	J:177468
Sirt2^tm1.1Cxd/Sirt2^tm1.1Cxd either: (involves: C57BL/6 * FVB/N) or (involves: FVB/N * NIH Black Swiss)	abnormal mitosis	J:177486
	aneuploidy	J:177486
	decreased fibroblast proliferation	J:177486
	delayed cellular replicative senescence	J:177486
	increased B cell derived lymphoma incidence	J:177486
	increased gastrointestinal tumor incidence	J:177486
	increased hepatocellular carcinoma incidence	J:177486
	increased lung tumor incidence	J:177486
	increased mammary gland tumor incidence	J:177486
	increased pancreas tumor incidence	J:177486
	increased prostate gland tumor incidence	J:177486
	increased stomach tumor incidence	J:177486
	increased tumor incidence	J:177486
	mammary gland hyperplasia	J:177486
Sirt2^tm1.1Fwa/Sirt2^tm1.1Fwa involves: 129S6/SvEvTac * C57BL/6	abnormal apoptosis	J:195041
	abnormal cell cycle	J:195041
	abnormal chromosome morphology	J:195041
	abnormal mitosis	J:195041
	abnormal tumor susceptibility	J:195041
	increased susceptibility to xenobiotic induced morbidity/mortality	J:195041
Sirt2^{tm1a(EUCOMM)Wtsi}/Sirt2^{tm1a(EUCOMM)Wtsi} B6JTyr;B6N-Sirt2^{tm1a(EUCOMM)Wtsi}/Wtsi	hyperactivity	J:165965
Sirt2^{tm1a(EUCOMM)Wtsi}/Sirt2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Sirt2^{tm1a(EUCOMM)Wtsi}/H	increased bone mineral density	J:165965
	increased circulating cholesterol level	J:165965
Sirt2^{tm1a(EUCOMM)Wtsi}/Sirt2^{tm1a(EUCOMM)Wtsi} involves: C57BL/6 * C57BL/6N	no abnormal phenotype detected	J:213427
Sirt2^tm1Gdon/Sirt2^tm1Gdon involves: 129P2/OlaHsd * C57BL/6	normal behavior/neurological phenotype	J:193012
	normal nervous system phenotype	J:193012

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23