Raph1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Raph1
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
MGI:1924550

19 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Raph1^tm1.1Makr/Raph1^tm1.1Makr involves: C57BL/6NTac	impaired fibroblast cell migration	J:208191
Raph1^tm1.1Makr/Raph1^tm1.1Makr Tg(Pgk1-cre)1Lni/0 involves: BALB/c * C57BL/6 * C57BL/6NTac	absent gastric milk in neonates	J:208191
	belly spot	J:208191
	decreased body size	J:208191
	infertility	J:208191
	neonatal lethality, incomplete penetrance	J:208191
	postnatal lethality, incomplete penetrance	J:208191
Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0 involves: C57BL/6 * C57BL/6NTac * FVB/N	belly spot	J:208191
	decreased body size	J:208191
	postnatal lethality, incomplete penetrance	J:208191
Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0 Tg(Dct-lacZ)A12Jkn/Tg(Dct-lacZ)A12Jkn involves: C57BL/6 * C57BL/6NTac * CBA * FVB/N	belly spot	J:208191
	decreased body size	J:208191
	decreased melanocyte number	J:208191
Raph1^tm1.2Fbg/Raph1^tm1.2Fbg involves: 129S4/SvJae * C57BL/6	abnormal colon morphology	J:238262
	abnormal cytokine level	J:238262
	abnormal rectum morphology	J:238262
	increased carcinoma incidence	J:238262
	increased inflammatory response	J:238262
	increased myeloid cell number	J:238262
	increased susceptibility to bacterial infection	J:238262
	intestinal edema	J:238262
	large intestinal inflammation	J:238262
	rectal prolapse	J:238262
Raph1^{tm1b(EUCOMM)Wtsi}/Raph1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Raph1^{tm1b(EUCOMM)Wtsi}/Wtsi	preweaning lethality, incomplete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23