Atg16l1 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atg16l1
autophagy related 16 like 1
MGI:1924290

13 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Api5^em1Cad/Api5⁺ Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/0 involves: C57BL/6J * C57BL/6N * SJL	abnormal Paneth cell morphology	J:340266
	decreased Paneth cell number	J:340266
Api5^em1Cad/Api5^em1Cad Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/0 involves: C57BL/6J * C57BL/6N * SJL	preweaning lethality, incomplete penetrance	J:340266
Atg16l1^{Gt(BC0122)Wtsi}/Atg16l1^{Gt(BC0122)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0 involves: 129P2/OlaHsd * C57BL/6NCrj	impaired autophagy	J:181308
Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tcrd^tm1Mom/Tcrd^tm1Mom Tg(Vil1-cre)997Gum/0 involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * SJL	abnormal cytokine level	J:340266
	abnormal Paneth cell morphology	J:340266
	decreased Paneth cell number	J:340266
	decreased small intestinal villus height	J:340266
	increased small intestinal crypt cell apoptosis	J:340266
	increased susceptibility to colitis induced morbidity/mortality	J:340266
Atg16l1^tm1Kuv/Atg16l1^tm1Kuv Tg(Vil1-cre)997Gum/0 Xbp1^tm2Glm/Xbp1^tm2Glm B6.Cg-Atg16l1^tm1Kuv Xbp1^tm2Glm Tg(Vil1-cre)997Gum	increased enterocyte apoptosis	J:269933
	small intestinal inflammation	J:269933
Atg16l1^tm1Kuv/Atg16l1^tm1Kuv Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Vil1-cre)997Gum/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal enterocyte physiology	J:206084
	ileum inflammation	J:206084
	intestinal inflammation	J:206084

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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