Cyrib Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyrib
CYFIP related Rac1 interactor B
MGI:1923520

22 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyrib^m1Ivdi/Cyrib^m1Ivdi involves: 129S1/Sv * 129X1/SvJ * DBA/2J	abnormal cecum morphology	J:282597
	abnormal large intestine goblet cell morphology	J:282597
	abnormal spleen morphology	J:282597
	abnormal spleen white pulp morphology	J:282597
	increased circulating interleukin-6 level	J:282597
	increased circulating interleukin-10 level	J:282597
	increased circulating tumor necrosis factor level	J:282597
	increased neutrophil cell number	J:282597
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282597
	intestinal edema	J:282597
	liver abscess	J:282597
	pulmonary parenchymal consolidation	J:282597
Cyrib^{tm1b(KOMP)Wtsi}/Cyrib⁺ C57BL/6N-Cyrib^{tm1b(KOMP)Wtsi}/Tcp	abnormal retina morphology	J:211773
	decreased circulating sodium level	J:211773
	decreased exploration in new environment	J:211773
Cyrib^{tm1b(KOMP)Wtsi}/Cyrib^{tm1b(KOMP)Wtsi} C57BL/6N-Cyrib^{tm1b(KOMP)Wtsi}/Tcp	abnormal retina morphology	J:211773
	edema	J:211773
	male infertility	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Cyrib^{tm1c(KOMP)Wtsi}/Cyrib^{tm1d(KOMP)Wtsi} Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * BcA17/Skmn * C57BL/6N	abnormal actin cytoskeleton morphology	J:282597
	abnormal circulating chemokine level	J:282597
	abnormal neutrophil physiology	J:282597
	increased circulating CXCL10 level	J:282597
	increased circulating interleukin-6 level	J:282597
	increased circulating interleukin-10 level	J:282597
	increased circulating tumor necrosis factor level	J:282597
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282597
	pulmonary parenchymal consolidation	J:282597

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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