Pik3r4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pik3r4
phosphoinositide-3-kinase regulatory subunit 4
MGI:1922919

22 phenotypes from 3 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Neurod6^tm1(cre)Kan/Neurod6⁺ Pik3r4^mbe/Pik3r4^tm1.1Mpnd involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C3H/HeH * C57BL/6	abnormal hippocampus pyramidal cell layer	J:258027
	abnormal hippocampus stratum oriens morphology	J:258027
	ectopic hippocampus pyramidal cells	J:258027
Pik3r4^mbe/Pik3r4^mbe involves: C3H/HeH * C57BL/6	abnormal autophagy	J:258027
	abnormal cell physiology	J:258027
	abnormal hippocampal pyramidal neuron dendrite morphology	J:258027
	abnormal hippocampus pyramidal cell layer	J:258027
	abnormal hippocampus stratum oriens morphology	J:258027
	abnormal neuronal migration	J:258027
	abnormal spatial working memory	J:258027
	ectopic hippocampus pyramidal cells	J:258027
Pik3r4^mbe/Pik3r4^tm1.1Mpnd Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S2/SvPas * C3H/HeH * C57BL/6	abnormal hippocampus pyramidal cell layer	J:258027
	abnormal hippocampus stratum oriens morphology	J:258027
	ectopic hippocampus pyramidal cells	J:258027
Pik3r4^tm1.1Mpnd/Pik3r4^tm1.1Mpnd involves: 129S2/SvPas * C57BL/6	abnormal neuronal migration	J:258027
Pik3r4^tm1.1Mpnd/Pik3r4^tm1.1Mpnd involves: 129S2/SvPas * C57BL/6N	no abnormal phenotype detected	J:198770
Pik3r4^tm1.1Mpnd/Pik3r4^tm1.1Mpnd involves: 129S2/SvPas * C57BL/6N	abnormal autophagy	J:198770
Pik3r4^tm1.1Mpnd/Pik3r4^tm1.1Mpnd Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S2/SvPas * C57BL/6	abnormal cerebral cortex morphology	J:258027
	abnormal hippocampus morphology	J:258027
	thin cerebral cortex	J:258027
Pik3r4^tm1.1Mpnd/Pik3r4^tm1.1Mpnd Tg(ACTA1-cre)79Jme/0 involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL	abnormal autophagy	J:198770
	abnormal sarcolemma morphology	J:198770
	centrally nucleated skeletal muscle fibers	J:198770
	increased circulating creatine kinase level	J:198770
	increased skeletal muscle glycogen level	J:198770
	muscle weakness	J:198770
	myopathy	J:198770
	myositis	J:198770
	skeletal muscle degeneration	J:198770
	skeletal muscle fiber necrosis	J:198770
Pik3r4^tm1.2Mpnd/Pik3r4^tm1.2Mpnd involves: 129S2/SvPas * BALB/cJ * C57BL/6N	embryonic lethality, complete penetrance	J:198770

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