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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nhej1
non-homologous end joining factor 1
MGI:1922820
25 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cyrentm1.1(KOMP)Vlcg/Cyrentm1.1(KOMP)Vlcg
Nhej1tm1Fwa/Nhej1tm1Fwa
involves: 129S6/SvEvTac * C57BL/6NTac 		decreased fetal size J:265834
increased neuron apoptosis J:265834
lethality throughout fetal growth and development, complete penetrance J:265834
Ercc6l2em1Mengf/Ercc6l2em1Mengf
Nhej1em1Mengf/Nhej1em1Mengf
Not Specified 		abnormal T cell receptor V(D)J recombination J:311900
Nhej1tm1.1Ics/Nhej1tm1.1Ics
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * C57BL/6 		abnormal T cell receptor V(D)J recombination J:194422
decreased NK T cell number J:194422
decreased thymocyte apoptosis J:194422
Nhej1tm1Fwa/Nhej1tm1Fwa
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129 		increased B cell derived lymphoma incidence J:138774
increased medulloblastoma incidence J:138774
increased T cell derived lymphoma incidence J:138774
Nhej1tm1Fwa/Nhej1tm1Fwa
Xrcc5tm1Nus/Xrcc5tm1Nus
involves: 129S6/SvEvTac * C57BL/6 		athymia J:236776
decreased body size J:236776
normal mortality/aging J:236776
small spleen J:236776
Paxxem1Spj/Paxxem1Spj
Nhej1tm1Fwa/Nhej1tm1Fwa
involves: 129S6/SvEvTac * C57BL/6NTac 		abnormal thymus involution J:236776
absent lymphocyte J:236776
athymia J:236776
chromosomal instability J:236776
decreased birth body size J:236776
decreased body size J:236776
decreased body weight J:236776
decreased embryo size J:236776
decreased fetal size J:236776
decreased fetal weight J:236776
decreased spleen weight J:236776
decreased splenocyte number J:236776
increased neural tube apoptosis J:236776
lethality throughout fetal growth and development, incomplete penetrance J:236776
postnatal lethality, incomplete penetrance J:236776
small spleen J:236776
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory