Tmprss12 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tmprss12
transmembrane (C-terminal) protease, serine 12
MGI:1922252

22 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tmprss12^em1Huizh/Tmprss12^em1Huizh C57BL/6-Tmprss12^em1Huizh	abnormal double-strand DNA break repair	J:324488
	abnormal male meiosis	J:324488
	abnormal mitochondrial ATP synthesis coupled electron transport	J:324488
	abnormal mitochondrial crista morphology	J:324488
	abnormal sperm midpiece morphology	J:324488
	abnormal sperm mitochondrial sheath morphology	J:324488
	abnormal sperm physiology	J:324488
	abnormal spermatogenesis	J:324488
	abnormal X-Y chromosome synapsis during male meiosis	J:324488
	asthenozoospermia	J:324488
	decreased fertilization frequency	J:324488
	decreased male germ cell number	J:324488
	decreased sperm progressive motility	J:324488
	impaired acrosome reaction	J:324488
	impaired sperm capacitation	J:324488
	increased male germ cell apoptosis	J:324488
	male infertility	J:324488
	oligozoospermia	J:324488
	normal reproductive system phenotype	J:324488
Tmprss12^em4Osb/Tmprss12^em4Osb involves: C57BL/6NJcl * DBA/2NJcl	asthenozoospermia	J:293874
	impaired binding of sperm to zona pellucida	J:293874
	impaired fertilization	J:293874
	impaired sperm migration in female genital tract	J:293874
	male infertility	J:293874

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23