51 phenotypes from 9 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pik3cbGt(OST147188)Lex/Pik3cbGt(OST147188)Lex involves: 129S5/SvEvBrd * C57BL/6J	decreased heart rate	J:103485
	preweaning lethality, complete penetrance	J:103485
Pik3cbtm1.1Bvan/Pik3cbtm1.1Bvan involves: 129P2/OlaHsd * C57BL/6	embryonic lethality, incomplete penetrance	J:136305
Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi B6.129P2-Pik3cbtm1.1Ehi	decreased liver glycogen level	J:152332
	impaired gluconeogenesis	J:152332
	increased circulating glucose level	J:152332
	increased insulin secretion	J:152332
	insulin resistance	J:152332
	pancreatic islet hyperplasia	J:152332
Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6J	decreased birth body size	J:152332
	decreased circulating cholesterol level	J:152332
	decreased circulating triglyceride level	J:152332
	decreased embryo size	J:152332
	decreased fibroblast proliferation	J:152332
	embryonic lethality during organogenesis, incomplete penetrance	J:152332
	lethality throughout fetal growth and development, incomplete penetrance	J:152332
	postnatal growth retardation	J:152332
Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi involves: 129/Sv * 129P2/OlaHsd * C57BL/6J	abnormal seminiferous tubule morphology	J:165087
	abnormal spermatogenesis	J:165087
	abnormal spermatogonia morphology	J:165087
	abnormal spermatogonia proliferation	J:165087
	abnormal testis interstitial tissue morphology	J:165087
	azoospermia	J:165087
	decreased male germ cell number	J:165087
	decreased testis weight	J:165087
	increased circulating follicle stimulating hormone level	J:165087
	increased testis apoptosis	J:165087
	oligozoospermia	J:165087
	reduced male fertility	J:165087
	normal reproductive system phenotype	J:165087
	small testis	J:165087
Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi involves: 129P2/OlaHsd	abnormal platelet physiology	J:152267
	decreased platelet aggregation	J:152267
Pik3cbtm1.1Jdo/Pik3cbtm1.1Jdo involves: C57BL/6	decreased body weight	J:198414
	decreased physiological sensitivity to xenobiotic	J:198414
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:198414
	embryonic lethality, incomplete penetrance	J:198414
	increased lung weight	J:198414
	pulmonary fibrosis	J:198414
	weight loss	J:198414
Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	normal cardiovascular system phenotype	J:166421
	decreased heart weight	J:166421
Pik3cbtm1a(EUCOMM)Wtsi/Pik3cb+ B6JTyr;B6N-Pik3cbtm1a(EUCOMM)Wtsi/Wtsi	decreased circulating creatinine level	J:175295
	increased hemoglobin content	J:175295
	increased mean corpuscular hemoglobin	J:175295
Pik3cbtm1a(EUCOMM)Wtsi/Pik3cbtm1a(EUCOMM)Wtsi B6JTyr;B6N-Pik3cbtm1a(EUCOMM)Wtsi/Wtsi	decreased lumbar vertebrae number	J:175295
	increased hemoglobin content	J:175295
	increased mean corpuscular hemoglobin	J:175295
Pik3cbtm1Bvan/Pik3cbtm1Bvan Tg(Pf4-icre)Q3Rsko/0 involves: 129P2/OlaHsd	decreased platelet aggregation	J:158839
Pik3cbtm1Bvan/Pik3cbtm1Bvan Tg(Tek-cre)1Ywa/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	normal cardiovascular system phenotype	J:136236
Pik3cbtm1Jjz/Pik3cbtm1Jjz involves: 129 * C57BL/6	abnormal cell physiology	J:138565
	decreased fibroblast proliferation	J:138565
	impaired glucose tolerance	J:138565
	increased circulating leptin level	J:138565
	insulin resistance	J:138565
Pik3cbtm1Jjz/Pik3cbtm1Jjz Tg(Pbsn-cre)4Prb/0 involves: 129 * C57BL/6 * DBA/2	normal neoplasm	J:138565
Pik3cbtm1Nbm/Pik3cbtm1Nbm involves: 129S6/SvEvTac	embryonic lethality before implantation, incomplete penetrance	J:75617
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:75617