Sgms2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sgms2
sphingomyelin synthase 2
MGI:1921692

18 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sgms2^tm1Jia/Sgms2^tm1Jia involves: 129 * C57BL/6	abnormal cell physiology	J:162192
	abnormal circulating protein level	J:162192
	abnormal hepatocyte physiology	J:162192
	abnormal lipid level	J:162192, J:162226
	abnormal macrophage morphology	J:162226
	abnormal macrophage physiology	J:162192, J:162226
	abnormal sphingomyelin level	J:162192
	hemolysis	J:162192
Sgms2^tm1Jia/Sgms2^tm1Jia Not Specified	abnormal ceramide level	J:220024, J:228568
	abnormal sphingomyelin level	J:228568
	normal homeostasis/metabolism phenotype	J:228568
Sgms2^tm1Kenw/Sgms2^tm1Kenw B6.129S2-Sgms2^tm1Kenw	abnormal cell physiology	J:175924
	abnormal circulating glucose level	J:175924
	decreased circulating triglyceride level	J:175924
	decreased epididymal fat pad weight	J:175924
	decreased susceptibility to diet-induced hepatic steatosis	J:175924
	decreased susceptibility to diet-induced obesity	J:175924
	improved glucose tolerance	J:175924
	increased circulating free fatty acids level	J:175924
	increased insulin sensitivity	J:175924

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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