Robo4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Robo4
roundabout guidance receptor 4
MGI:1921394

20 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Robo4^{tm1.1(KOMP)Vlcg}/Robo4^{tm1.1(KOMP)Vlcg} C57BL/6N-Robo4^{tm1.1(KOMP)Vlcg}/MbpMmucd	preweaning lethality, complete penetrance	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Robo4^tm1.1Xby/Robo4^tm1.1Xby involves: C57BL/6	abnormal telencephalon development	J:202213
Robo4^tm1.1Xby/Robo4^tm1.1Xby Emx1^tm1(cre)Ito/Emx1⁺ involves: 129P2/OlaHsd * C57BL/6	normal nervous system phenotype	J:202213
Robo4^tm1Kzh/Robo4^tm1Kzh involves: C57BL/6	abnormal angiogenesis	J:133680
	abnormal diaphragm morphology	J:208012
	abnormal lung endothelial cell migration	J:133680
	abnormal vascular development	J:208012
	abnormal vascular permeability	J:133680
	decreased angiogenesis	J:208012
	impaired skin barrier function	J:133680
	pathological neovascularization	J:133680
Robo4^tm1Kzh/Robo4^tm1Kzh Not Specified	decreased circulating glucose level	J:294754
	decreased fasting circulating glucose level	J:294754
	decreased susceptibility to diet-induced obesity	J:294754
	enhanced exercise endurance	J:294754
	normal growth/size/body region phenotype	J:294754
	improved glucose tolerance	J:294754
	increased angiogenesis	J:294754
	increased vasodilation	J:294754

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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