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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Wasl
WASP like actin nucleation promoting factor
MGI:1920428
70 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Wasltm1.1Cgn/Wasltm1.1Cgn
C57BL/6-Wasltm1.1Cgn
abnormal allantois morphology J:73609
abnormal ectoplacental cavity morphology J:73609
abnormal extraembryonic mesoderm development J:73609
abnormal gastrulation J:73609
abnormal mesoderm development J:73609
decreased embryo size J:73609
failure of initiation of embryo turning J:73609
prenatal lethality, complete penetrance J:73609
Wasltm1.1Sbs/Wasltm1.1Sbs
either: (involves: 129P2/OlaHsd * 129S/SvEv) or (involves: 129P2/OlaHsd * C57BL/6)
prenatal lethality, complete penetrance J:72053
Wasltm1.1Ttha/Wasl+
Tg(Nes-cre)1Kag/0
involves: C57BL/6 * SJL
no abnormal phenotype detected J:207484
Wasltm1.1Ttha/Wasltm1.1Ttha
Tg(KRT14-cre)1Amc/0
involves: C57BL/6 * C57BL/6N * CBA
abnormal circulating chemokine level J:271857
abnormal esophagus morphology J:271857
abnormal skin appearance J:271857
alopecia J:271857
decreased body weight J:271857
dermatitis J:271857
dilated esophagus J:271857
dry skin J:271857
epidermal hyperplasia J:271857
impaired skin barrier function J:271857
increased circulating interleukin-1 alpha level J:271857
increased circulating interleukin-6 level J:271857
increased circulating interleukin-17 level J:271857
increased circulating tumor necrosis factor level J:271857
increased keratinocyte proliferation J:271857
increased susceptibility to bacterial infection J:271857
postnatal growth retardation J:271857
premature death J:271857
scaly skin J:271857
skin inflammation J:271857
thick epidermis J:271857
wrinkled skin J:271857
Wasltm1.1Ttha/Wasltm1.1Ttha
Tg(Nes-cre)1Kag/0
involves: C57BL/6 * SJL
abnormal brain ependyma morphology J:207484
abnormal brain vasculature morphology J:207484
abnormal cerebral aqueduct morphology J:207484
abnormal cerebral cortex morphology J:207484
abnormal choroid plexus morphology J:207484
abnormal dorsal striatum morphology J:207484
abnormal gait J:207484
abnormal postnatal subventricular zone morphology J:207484
abnormal septum of telencephalon morphology J:207484
abnormal spine curvature J:207484
absent brain ependyma motile cilia J:207484
absent hippocampus J:207484
astrocytosis J:207484
cerebral aqueductal stenosis J:207484
decreased body size J:207484
decreased body weight J:207484
decreased corpus callosum size J:207484
dilated fourth ventricle J:207484
dilated lateral ventricle J:207484
domed cranium J:207484
enlarged brain ventricles J:207484
enlarged cranium J:207484
hydrocephaly J:207484
increased brain size J:207484
kyphosis J:207484
lethargy J:207484
obstructive hydrocephaly J:207484
postnatal growth retardation J:207484
postnatal lethality, complete penetrance J:207484
thin cerebral cortex J:207484
Wasltm1Cgn/Wasltm1Cgn
C57BL/6-Wasltm1Cgn
no abnormal phenotype detected J:73609
Wasltm1Sbs/Wasltm1Sbs
either: (involves: 129P2/OlaHsd * 129S/SvEv) or (involves: 129P2/OlaHsd * C57BL/6)
abnormal cell chemotaxis J:72053
absent heartbeat J:72053
decreased embryo size J:72053
decreased fibroblast proliferation J:72053
delayed embryo turning J:72053
dilated heart J:72053
embryonic growth retardation J:72053
embryonic lethality during organogenesis, complete penetrance J:72053
wavy neural tube J:72053
Wasltm2Sbs/Wasltm2Sbs
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * C57BL/6J
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
renal hypoplasia J:195266

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory