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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cul4b
cullin 4B
MGI:1919834
38 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cul4bGt(M119G06)Wrst/Y
chimera involves: 129S2/SvPas
abnormal developmental patterning J:160967
Cul4btm1.1Pz/Y
involves: 129 * C57BL/6J
no abnormal phenotype detected J:199210
Cul4btm1.1Pz/Cul4b+
Tg(CAG-cre)13Miya/0
involves: 129 * C57BL/6 * C57BL/6J
abnormal vitelline vasculature morphology J:199210
lethality throughout fetal growth and development, complete penetrance J:199210
Cul4btm1.1Pz/Cul4b+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * C57BL/6J * CBA
normal mortality/aging J:199210
Cul4btm1.1Pz/Cul4btm1.1Pz
involves: 129 * C57BL/6J
no abnormal phenotype detected J:199210
Cul4btm1.1Pz/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * C57BL/6J * CBA
no abnormal phenotype detected J:199210
Cul4btm1.1Pz/Y
Tg(CAG-cre)13Miya/0
involves: 129 * C57BL/6 * C57BL/6J
abnormal ectoderm development J:199210
abnormal embryo development J:199210
absent ectoplacental cone J:199210
decreased cell proliferation J:199210
decreased embryo size J:199210
embryonic growth arrest J:199210
embryonic lethality during organogenesis, complete penetrance J:199210
failure of primitive streak formation J:199210
increased embryonic tissue cell apoptosis J:199210
Cul4btm1.1Yxg/Y
involves: 129X1/SvJ * FVB/N
abnormal embryonic tissue morphology J:199139
abnormal extraembryonic tissue morphology J:199139
decreased cell proliferation J:199139
decreased embryo size J:199139
disorganized extraembryonic tissue J:199139
embryonic growth retardation J:199139
embryonic lethality during organogenesis, complete penetrance J:199139
increased embryonic tissue cell apoptosis J:199139
Cul4btm1.1Yxg/Cul4b+
involves: 129X1/SvJ * FVB/N
abnormal dosage compensation, by inactivation of X chromosome J:199139
abnormal placenta labyrinth morphology J:199139
abnormal visceral yolk sac morphology J:199139
decreased body size J:199139
decreased body weight J:199139
decreased embryo size J:199139
decreased fetal size J:199139
disorganized placental labyrinth J:199139
embryonic growth retardation J:199139
fetal growth retardation J:199139
lethality during fetal growth through weaning, incomplete penetrance J:199139
lethality throughout fetal growth and development, incomplete penetrance J:199139
pale placenta J:199139
pallor J:199139
postnatal growth retardation J:199139
small placenta J:199139
Cul4btm1Swl/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
B6.Cg-Edil3Tg(Sox2-cre)1Amc Cul4btm1Swl
abnormal dendrite morphology J:187403
abnormal dendritic spine morphology J:187403
abnormal spatial learning J:187403
abnormal spatial working memory J:187403
decreased neuron number J:187403
increased susceptibility to pharmacologically induced seizures J:187403
Cul4btm1Yxg/Y
involves: 129X1/SvJ
no abnormal phenotype detected J:199139
Cul4btm1Yxg/Cul4btm1Yxg
involves: 129X1/SvJ
no abnormal phenotype detected J:199139

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory