Ifih1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ifih1
interferon induced with helicase C domain 1
MGI:1918836

37 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ifih1^{em1(IMPC)Wtsi}/Ifih1^{em1(IMPC)Wtsi} C57BL/6N-Ifih1^{em1(IMPC)Wtsi}/Wtsi	increased circulating magnesium level	J:211773
Ifih1^Rgsc422/Ifih1⁺ D2JJcl.B6JJcl-Ifih1^Rgsc422	abnormal chemokine level	J:209917
	abnormal cytokine level	J:209917
	abnormal dendritic cell antigen presentation	J:209917
	abnormal leukocyte cell number	J:209917
	abnormal macrophage activation involved in immune response	J:209917
	abnormal T cell activation	J:209917
	autoimmune response	J:209917
	chronic liver inflammation	J:209917
	decreased survivor rate	J:209917
	glomerulonephritis	J:209917
	increased anti-double stranded DNA antibody level	J:209917
	increased anti-nuclear antigen antibody level	J:209917
	increased dendritic cell number	J:209917
	increased granulocyte number	J:209917
	increased IgA level	J:209917
	increased IgG level	J:209917
	increased IgM level	J:209917
	increased immunoglobulin level	J:209917
	increased inflammatory response	J:209917
	increased macrophage cell number	J:209917
	increased plasma cell number	J:209917
	increased susceptibility to systemic lupus erythematosus	J:209917
	mixed cellular infiltration to dermis	J:209917
	postnatal growth retardation	J:209917
	skin inflammation	J:209917
Ifih1^Rgsc422/Ifih1^Rgsc422 D2JJcl.B6JJcl-Ifih1^Rgsc422	decreased survivor rate	J:209917
	glomerulonephritis	J:209917
	increased susceptibility to systemic lupus erythematosus	J:209917
	postnatal growth retardation	J:209917
	postnatal lethality	J:209917
Ifih1^tm1.1Cln/Ifih1^tm1.1Cln involves: 129X1/SvJ	decreased interferon-beta secretion	J:240099
Ifih1^tm1.1Cln/Ifih1^tm1.1Cln involves: 129X1/SvJ * C57BL/6	abnormal cytokine secretion	J:110201
	decreased interferon-alpha secretion	J:110201
	decreased interleukin-6 secretion	J:110201
	increased susceptibility to induced morbidity/mortality	J:110201
	increased susceptibility to Picornaviridae infection	J:110201
Ifih1^tm1Aki/Ifih1^tm1Aki involves: 129/Sv * C57BL/6	abnormal cell physiology	J:137522
	abnormal dendritic cell physiology	J:137522
	abnormal interferon level	J:137522
	abnormal interleukin level	J:137522
	increased susceptibility to Picornaviridae infection	J:137522

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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