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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wnk4
WNK lysine deficient protein kinase 4
MGI:1917097
19 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc12a3tm1Ges/Slc12a3tm1Ges
Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
involves: C3H * C57BL/6 		normal cardiovascular system phenotype J:113094
normal homeostasis/metabolism phenotype J:113094
normal renal/urinary system phenotype J:113094
Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
involves: C3H * C57BL/6 		abnormal distal convoluted tubule morphology J:113094
normal cardiovascular system phenotype J:113094
decreased circulating chloride level J:113094
decreased circulating magnesium level J:113094
decreased circulating potassium level J:113094
decreased systemic arterial diastolic blood pressure J:113094
decreased systemic arterial systolic blood pressure J:113094
decreased urine calcium level J:113094
Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
involves: C3H * C57BL/6 		abnormal distal convoluted tubule morphology J:113094
abnormal kidney physiology J:113094
normal cardiovascular system phenotype J:113094
decreased circulating bicarbonate level J:113094
hyperkalemia J:113094
increased circulating chloride level J:113094
increased circulating magnesium level J:113094
increased systemic arterial diastolic blood pressure J:113094
increased systemic arterial systolic blood pressure J:113094
increased urine calcium level J:113094
premature death J:113094
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory