A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
decreased common lymphocyte progenitor cell number |
J:259392
|
|
normal
immune system phenotype |
J:259392
|
Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca
|
normal
respiratory system phenotype |
J:196943
|
Adh5tm1.1Llli/Adh5tm1.1Llli
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Adh5tm1.1Llli Commd10Tg(Vav1-icre)A2Kio
|
normal
mortality/aging |
J:173666
|
Atg7tm1Tchi/Atg7tm1Tchi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
|
abnormal common lymphocyte progenitor cell morphology |
J:176843
|
|
abnormal hematopoietic stem cell morphology |
J:176843
|
|
abnormal hematopoietic stem cell physiology |
J:176843
|
|
abnormal leukocyte morphology |
J:176843
|
|
decreased B cell number |
J:176843
|
|
decreased bone marrow cell number |
J:176843
|
|
decreased common myeloid progenitor cell number |
J:176843
|
|
decreased hematopoietic stem cell number |
J:176843
|
|
decreased leukocyte cell number |
J:176843
|
|
decreased NK cell number |
J:176843
|
|
decreased T cell number |
J:176843
|
Atp6v0a2tm1Kdb/Atp6v0a2tm1Kdb
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology |
J:274048
|
|
decreased alpha-beta T cell number |
J:274048
|
|
decreased CD4-positive, alpha-beta T cell number |
J:274048
|
|
decreased T cell number |
J:274048
|
|
decreased tumor latency |
J:274048
|
|
increased incidence of induced tumors |
J:274048
|
|
increased metastatic potential |
J:274048
|
Bcl11atm1Pwt/Bcl11atm1Pwt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
decreased B cell number |
J:207383
|
|
decreased circulating interferon-alpha level |
J:207383
|
|
decreased hematopoietic stem cell number |
J:207383
|
|
decreased plasmacytoid dendritic cell number |
J:207383
|
|
normal
hematopoietic system phenotype |
J:207383
|
Bcortm1.1Vjba/Y
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * C57BL/6 * CBA/Ca
|
increased neutrophil cell number |
J:231455
|
Bmi1tm1Sgon/Bmi1tm1Sgon
Commd10Tg(Vav1-icre)A2Kio/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
|
abnormal erythropoiesis |
J:221849
|
|
abnormal hemopoiesis |
J:221849
|
|
abnormal immune system cell morphology |
J:221849
|
|
abnormal immune system organ morphology |
J:221849
|
|
abnormal spleen morphology |
J:221849
|
|
abnormal spleen periarteriolar lymphoid sheath morphology |
J:221849
|
|
abnormal spleen white pulp morphology |
J:221849
|
|
abnormal thymus morphology |
J:221849
|
|
absent spleen germinal center |
J:221849
|
|
decreased B cell number |
J:221849
|
|
decreased bone marrow cell number |
J:221849
|
|
decreased common myeloid progenitor cell number |
J:221849
|
|
decreased hematopoietic stem cell number |
J:221849
|
|
decreased myeloid cell number |
J:221849
|
|
decreased spleen red pulp amount |
J:221849
|
|
decreased spleen white pulp amount |
J:221849
|
|
decreased T cell number |
J:221849
|
|
increased common lymphocyte progenitor cell number |
J:221849
|
|
premature death |
J:221849
|
|
small spleen |
J:221849
|
|
small thymus |
J:221849
|
|
thymus atrophy |
J:221849
|
Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
|
abnormal cell physiology |
J:240552
|
Cd40lgtm1Parl/Cd40lgtm1Parl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
|
decreased IgM level |
J:213459
|
|
normal
hematopoietic system phenotype |
J:213459
|
|
normal
homeostasis/metabolism phenotype |
J:213459
|
|
increased IgG1 level |
J:213459
|
|
thrombocytopenia |
J:213459
|
Cd40lgtm1Parl/Y
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
|
decreased IgM level |
J:213459
|
|
normal
hematopoietic system phenotype |
J:213459
|
|
normal
homeostasis/metabolism phenotype |
J:213459
|
|
increased IgG1 level |
J:213459
|
|
thrombocytopenia |
J:213459
|
Cdh5tm8Dvst/Cdh5tm8Dvst
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/10 * CBA/Ca
|
normal
liver/biliary system phenotype |
J:213676
|
Cdk5rap3tm1c(EUCOMM)Hmgu/Cdk5rap3tm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S4/SvJaeSor * C57BL/6N * C57BL/10 * CBA/Ca
|
abnormal hemopoiesis |
J:272566
|
|
normal
mortality/aging |
J:272566
|
Cdkn1atm1Led/Cdkn1atm1Led
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio
|
arrested T cell differentiation |
J:170508
|
Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
|
abnormal bone marrow cell morphology/development |
J:266848
|
|
decreased bone marrow cell number |
J:266848
|
|
decreased hematopoietic stem cell number |
J:266848
|
Chaf1btm2c(EUCOMM)Hmgu/Chaf1btm2c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
|
prenatal lethality, complete penetrance |
J:266848
|
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Ociad1tm1Msin/Ociad1tm1Msin
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
|
increased hematopoietic cell number |
J:279239
|
|
increased hematopoietic stem cell number |
J:279239
|
Commd10Tg(Vav1-icre)A2Kio/0
Map3k7tm1.1Arte/Map3k7tm1.1Arte
involves: C57BL/10 * C57BL/6J * C57BL/6NTac * CBA/Ca
|
decreased interleukin-6 secretion |
J:332172
|
|
decreased interleukin-10 secretion |
J:332172
|
|
decreased interleukin-12b secretion |
J:332172
|
|
decreased macrophage cell number |
J:332172
|
|
decreased tumor necrosis factor secretion |
J:332172
|
|
enlarged axillary lymph nodes |
J:332172
|
|
enlarged inguinal lymph nodes |
J:332172
|
|
enlarged spleen |
J:332172
|
|
increased B cell number |
J:332172
|
|
increased lymphocyte cell number |
J:332172
|
|
increased neutrophil cell number |
J:332172
|
|
increased splenocyte number |
J:332172
|
Commd10Tg(Vav1-icre)A2Kio/0
Nfil3tm1.2Kubo/Nfil3tm1.2Kubo
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
|
decreased dendritic cell number |
J:334296
|
Commd10Tg(Vav1-icre)A2Kio/?
Tnfrsf14tm1.1Kro/Tnfrsf14tm1.1Kro
involves: C57BL/6NCrl * C57BL/10 * CBA * SJL
|
abnormal blinking |
J:243038
|
|
decreased susceptibility to Herpesvirales infection |
J:243038
|
Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Commd10Tg(Vav1-icre)A2Kio/?
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
normal
hematopoietic system phenotype |
J:194748
|
Dhx36tm1.2Pmt/Dhx36tm1.2Pmt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal cell cycle |
J:185179
|
|
abnormal erythrocyte physiology |
J:185179
|
|
abnormal erythropoiesis |
J:185179
|
|
abnormal proerythroblast morphology |
J:185179
|
|
anemia |
J:185179
|
|
decreased erythroblast number |
J:185179
|
|
decreased erythrocyte cell number |
J:185179
|
|
decreased granulocyte monocyte progenitor cell number |
J:185179
|
|
decreased hemoglobin content |
J:185179
|
|
enlarged liver |
J:185179
|
|
enlarged spleen |
J:185179
|
|
hemolytic anemia |
J:185179
|
|
increased erythroblast number |
J:185179
|
|
increased hematopoietic stem cell number |
J:185179
|
|
increased mean corpuscular volume |
J:185179
|
|
increased megakaryocyte-erythroid progenitor cell number |
J:185179
|
|
intermingled spleen red and white pulp |
J:185179
|
|
pale kidney |
J:185179
|
|
pale liver |
J:185179
|
|
pallor |
J:185179
|
|
reticulocytosis |
J:185179
|
|
spherocytosis |
J:185179
|
|
thymus hypoplasia |
J:185179
|
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Egln1tm2.1Fsl Commd10Tg(Vav1-icre)A2Kio
|
increased erythroid progenitor cell number |
J:202737
|
|
increased hematocrit |
J:202737
|
|
increased hemoglobin content |
J:202737
|
|
polycythemia |
J:202737
|
F8tm1.1Rmnt/F8tm1.1Rmnt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL
|
decreased circulating factor VIII level |
J:212401
|
Fbxo21em1Smbk/Fbxo21em1Smbk
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Fbxo21em1Smbk Commd10Tg(Vav1-icre)A2Kio
|
abnormal bone marrow cell physiology |
J:333469
|
|
abnormal stress erythropoiesis |
J:333469
|
|
decreased spleen weight |
J:333469
|
|
increased granulocyte monocyte progenitor cell number |
J:333469
|
|
increased susceptibility to induced morbidity/mortality |
J:333469
|
|
increased T cell number |
J:333469
|
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
|
abnormal bone marrow cell morphology/development |
J:203163
|
|
abnormal hematopoietic system morphology/development |
J:203163
|
|
anemia |
J:203163
|
|
decreased common myeloid progenitor cell number |
J:203163
|
|
decreased erythroid progenitor cell number |
J:203163
|
|
preweaning lethality, incomplete penetrance |
J:203163
|
Gt(ROSA)26Sortm1(CAG-PSTPIP1)Dtg/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
no abnormal phenotype detected |
J:196002
|
Gt(ROSA)26Sortm2(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
normal
behavior/neurological phenotype |
J:196002
|
|
normal
growth/size/body region phenotype |
J:196002
|
|
normal
immune system phenotype |
J:196002
|
Idh1tm1Mak/Idh1tm1Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal common lymphocyte progenitor cell morphology |
J:186700
|
|
abnormal common myeloid progenitor cell morphology |
J:186700
|
|
normal
hematopoietic system phenotype |
J:186700
|
|
increased hematopoietic stem cell number |
J:186700
|
Idh1tm2Mak/Idh1tm2Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal common lymphocyte progenitor cell morphology |
J:186700
|
|
abnormal common myeloid progenitor cell morphology |
J:186700
|
|
normal
hematopoietic system phenotype |
J:186700
|
|
increased hematopoietic stem cell number |
J:186700
|
Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio
|
increased susceptibility to bacterial infection |
J:206257
|
|
increased susceptibility to bacterial infection induced morbidity/mortality |
J:206257
|
Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
|
abnormal immunoglobulin heavy chain V(D)J recombination |
J:137719
|
|
normal
immune system phenotype |
J:137719
|
Il22tm1.1Lex/Il22tm1.1Lex
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca
|
decreased physiological sensitivity to xenobiotic |
J:305794
|
|
increased erythrocyte cell number |
J:305794
|
Il22tm1.1Lex/Il22tm1.1Lex
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca
|
decreased physiological sensitivity to xenobiotic |
J:305794
|
|
increased erythrocyte cell number |
J:305794
|
|
increased erythroid progenitor cell number |
J:305794
|
Il22ra1tm1.1Koll/Il22ra1tm1.1Koll
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca
|
normal
hematopoietic system phenotype |
J:305794
|
Jagn1tm1c(EUCOMM)Hmgu/Jagn1tm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca
|
abnormal neutrophil morphology |
J:214828
|
|
abnormal neutrophil physiology |
J:214828
|
|
impaired neutrophil chemotaxis |
J:214828
|
|
impaired neutrophil recruitment |
J:214828
|
|
increased susceptibility to fungal infection |
J:214828
|
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal blood coagulation |
J:257910
|
|
abnormal blood vessel morphology |
J:257910
|
|
abnormal cytokine level |
J:257910
|
|
abnormal erythrocyte morphology |
J:257910
|
|
abnormal thrombosis |
J:257910
|
|
enlarged spleen |
J:257910
|
|
extramedullary hematopoiesis |
J:257910
|
|
increased erythrocyte cell number |
J:257910
|
|
increased erythroid progenitor cell number |
J:257910
|
|
increased granulocyte number |
J:257910
|
|
increased heart rate |
J:257910
|
|
increased leukocyte cell number |
J:257910
|
|
increased megakaryocyte cell number |
J:257910
|
|
increased megakaryocyte progenitor cell number |
J:257910
|
|
increased neutrophil cell number |
J:257910
|
|
limb paralysis |
J:257910
|
|
premature death |
J:257910
|
|
reticulocytosis |
J:257910
|
|
tachypnea |
J:257910
|
|
thrombocytosis |
J:257910
|
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
|
decreased mean corpuscular hemoglobin |
J:220728
|
|
decreased mean corpuscular volume |
J:220728
|
|
increased erythrocyte cell number |
J:220728
|
|
increased hematocrit |
J:220728
|
|
increased hemoglobin content |
J:220728
|
|
reticulocytosis |
J:220728
|
|
thrombocytosis |
J:220728
|
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
|
abnormal iron homeostasis |
J:220728
|
|
decreased CD4-positive, alpha-beta T cell number |
J:220728
|
|
decreased CD8-positive, alpha-beta T cell number |
J:220728
|
|
decreased erythrocyte cell number |
J:220728
|
|
decreased hematocrit |
J:220728
|
|
decreased hemoglobin content |
J:220728
|
|
decreased mean corpuscular hemoglobin |
J:220728
|
|
decreased mean corpuscular volume |
J:220728
|
|
hypochromic microcytic anemia |
J:220728
|
|
reticulocytosis |
J:220728
|
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal definitive hematopoiesis |
J:201572
|
|
decreased body size |
J:201572
|
|
decreased bone marrow cell number |
J:201572
|
|
decreased common myeloid progenitor cell number |
J:201572
|
|
decreased erythrocyte cell number |
J:201572
|
|
decreased hematopoietic stem cell number |
J:201572
|
|
decreased leukocyte cell number |
J:201572
|
|
postnatal lethality, incomplete penetrance |
J:201572
|
|
thrombocytopenia |
J:201572
|
Kitltm2.1Sjm/Kitltm2.2Sjm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: BALB/cJ * C57BL * CBA/Ca * SJL
|
decreased hematopoietic cell number |
J:180431
|
|
normal
hematopoietic system phenotype |
J:180431
|
Kmt2atm1Brad/Kmt2atm1Brad
Commd10Tg(Vav1-icre)A2Kio/?
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal bone marrow cell physiology |
J:149811
|
|
decreased common myeloid progenitor cell number |
J:149811
|
|
decreased pre-B cell number |
J:149811
|
Kmt5btm1Jnw/Kmt5btm1Jnw
Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca
|
abnormal class switch recombination |
J:139510
|
|
abnormal lymphopoiesis |
J:139510
|
|
decreased B cell number |
J:139510
|
|
decreased double-positive T cell number |
J:139510
|
|
normal
immune system phenotype |
J:139510
|
Lmo4tm1Slp/Lmo4tm1Slp
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal acute inflammation |
J:282740
|
|
abnormal gut-associated lymphoid tissue morphology |
J:282740
|
|
abnormal lymphocyte physiology |
J:282740
|
|
abnormal lymphopoiesis |
J:282740
|
|
decreased Peyer's patch number |
J:282740
|
|
increased susceptibility to bacterial infection |
J:282740
|
Lmo4tm1Slp/Lmo4tm1Slp
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal acute inflammation |
J:282740
|
|
abnormal lymphocyte physiology |
J:282740
|
|
abnormal lymphopoiesis |
J:282740
|
|
increased susceptibility to bacterial infection |
J:282740
|
Ly6etm1c(EUCOMM)Hmgu/Ly6etm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Ly6etm1c(EUCOMM)Hmgu Commd10Tg(Vav1-icre)A2Kio
|
abnormal liver morphology |
J:291868
|
|
abnormal mononuclear cell morphology |
J:291868
|
|
decreased B cell number |
J:291868
|
|
decreased CD4-positive, alpha-beta T cell number |
J:291868
|
|
decreased dendritic cell number |
J:291868
|
|
decreased inflammatory response |
J:291868
|
|
decreased macrophage cell number |
J:291868
|
|
decreased neutrophil cell number |
J:291868
|
|
decreased NK cell number |
J:291868
|
|
hepatic necrosis |
J:291868
|
|
increased circulating alanine transaminase level |
J:291868
|
|
increased susceptibility to Coronaviridae infection |
J:291868
|
|
increased susceptibility to Coronaviridae infection induced morbidity/mortality |
J:291868
|
|
pale liver |
J:291868
|
Myd88tm1Defr/Myd88tm1Defr
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/6 * SJL
|
abnormal NK cell physiology |
J:139001
|
Patz1tm1.2Welm/Patz1tm1.2Welm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Patz1tm1.2Welm Commd10Tg(Vav1-icre)A2Kio
|
abnormal mast cell differentiation |
J:209168
|
|
decreased interleukin-6 secretion |
J:209168
|
|
normal
immune system phenotype |
J:209168
|
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
|
abnormal iron homeostasis |
J:220728
|
|
decreased CD4-positive, alpha-beta T cell number |
J:220728
|
|
decreased CD8-positive, alpha-beta T cell number |
J:220728
|
|
decreased erythrocyte cell number |
J:220728
|
|
decreased mean corpuscular hemoglobin |
J:220728
|
|
decreased mean corpuscular volume |
J:220728
|
|
increased circulating erythropoietin level |
J:220728
|
|
microcytic anemia |
J:220728
|
|
reticulocytosis |
J:220728
|
Piezo1tm2.1Apat/Piezo1tm2.1Apat
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA
|
abnormal calcium ion homeostasis |
J:229436
|
|
abnormal erythrocyte ion transport |
J:229436
|
|
abnormal spleen morphology |
J:229436
|
|
abnormal splenic cell ratio |
J:229436
|
|
decreased blood osmolality |
J:229436
|
|
decreased circulating haptoglobin level |
J:229436
|
|
decreased erythrocyte cell number |
J:229436
|
|
decreased hematocrit |
J:229436
|
|
decreased mean corpuscular hemoglobin concentration |
J:229436
|
|
increased erythrocyte osmotic fragility |
J:229436
|
|
increased mean corpuscular hemoglobin |
J:229436
|
|
increased mean corpuscular volume |
J:229436
|
|
increased red blood cell distribution width |
J:229436
|
|
macrocytosis |
J:229436
|
Pkn3tm1.1Mrl/Pkn3tm1.1Mrl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Pkn3tm1.1Mrl Commd10Tg(Vav1-icre)A2Kio
|
normal
hematopoietic system phenotype |
J:216983
|
Plek2tm1Pji/Plek2tm1Pji
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal cell differentiation |
J:257910
|
|
abnormal granulocyte differentiation |
J:257910
|
|
abnormal megakaryocyte differentiation |
J:257910
|
|
extramedullary hematopoiesis |
J:257910
|
|
normal
hematopoietic system phenotype |
J:257910
|
|
normal
homeostasis/metabolism phenotype |
J:257910
|
|
normal
immune system phenotype |
J:257910
|
|
premature death |
J:257910
|
Rbpjtm1Hon/Rbpjtm1Hon
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
|
decreased tumor growth/size |
J:162770
|
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
|
abnormal B cell differentiation |
J:177784
|
|
abnormal effector T cell morphology |
J:177784
|
|
abnormal germinal center B cell physiology |
J:177784
|
|
abnormal spleen B cell follicle morphology |
J:177784
|
|
decreased B cell number |
J:177784
|
|
decreased bone marrow cell number |
J:177784
|
|
decreased IgA level |
J:177784
|
|
decreased IgG1 level |
J:177784
|
|
decreased IgG3 level |
J:177784
|
|
decreased immature B cell number |
J:177784
|
|
enlarged spleen |
J:177784
|
|
normal
immune system phenotype |
J:177784
|
|
increased eosinophil cell number |
J:177784
|
|
increased IgG2b level |
J:177784
|
|
increased macrophage cell number |
J:177784
|
|
increased regulatory T cell number |
J:177784
|
|
increased spleen weight |
J:177784
|
|
increased splenocyte number |
J:177784
|
|
spleen hyperplasia |
J:177784
|
Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal NK cell morphology |
J:282535
|
|
decreased NK cell number |
J:282535
|
|
small spleen |
J:282535
|
Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Rptortm1.1Dmsa/Rptor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S/SvEv * C57BL/10 * CBA/Ca
|
abnormal NK cell morphology |
J:282535
|
|
decreased NK cell number |
J:282535
|
|
small spleen |
J:282535
|
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca
|
abnormal bone marrow cell physiology |
J:305794
|
|
abnormal CD4-positive, alpha beta T cell morphology |
J:305794
|
|
abnormal CD4-positive, alpha-beta T cell physiology |
J:305794
|
|
abnormal circulating interleukin level |
J:305794
|
|
abnormal erythropoiesis |
J:305794
|
|
abnormal hematopoietic system physiology |
J:305794
|
|
abnormal immune system morphology |
J:305794
|
|
abnormal interleukin secretion |
J:305794
|
|
anemia |
J:305794
|
|
decreased erythrocyte cell number |
J:305794
|
|
decreased erythroid progenitor cell number |
J:305794
|
|
decreased hematocrit |
J:305794
|
|
decreased hemoglobin content |
J:305794
|
|
decreased neutrophil cell number |
J:305794
|
|
increased granulocyte monocyte progenitor cell number |
J:305794
|
|
increased hematopoietic stem cell number |
J:305794
|
|
increased monocyte cell number |
J:305794
|
|
increased myeloid cell number |
J:305794
|
|
increased NK T cell number |
J:305794
|
|
increased physiological sensitivity to xenobiotic |
J:305794
|
|
increased susceptibility to xenobiotic induced morbidity/mortality |
J:305794
|
Riok2tm1c(KOMP)Wtsi/Riok2tm1c(KOMP)Wtsi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca
|
prenatal lethality, complete penetrance |
J:305794
|
Rr7tm3.1Kio/Rr7+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
|
normal
immune system phenotype |
J:179326
|
Satb1tm2Kos/Satb1tm2Kos
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal renal glomerulus morphology |
J:252606
|
|
absent regulatory T cells |
J:252606
|
|
decreased salivation |
J:252606
|
|
increased anti-nuclear antigen antibody level |
J:252606
|
|
increased autoantibody level |
J:252606
|
|
increased susceptibility to autoimmune disorder |
J:252606
|
|
increased urine protein level |
J:252606
|
|
kidney inflammation |
J:252606
|
|
pancreas inflammation |
J:252606
|
|
premature death |
J:252606
|
|
salivary gland degeneration |
J:252606
|
|
salivary gland inflammation |
J:252606
|
Snai1tm1.1Stjw/Snai1tm1.1Stjw
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Snai1tm1.1Stjw Commd10Tg(Vav1-icre)A2Kio
|
no abnormal phenotype detected |
J:214991
|
Sppl3tm1Itl/Sppl3tm1Itl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S/SvEv * C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal NK cell differentiation |
J:280182
|
|
decreased mature NK cell number |
J:280182
|
|
decreased NK cell number |
J:280182
|
|
normal
hematopoietic system phenotype |
J:280182
|
|
normal
immune system phenotype |
J:280182
|
|
impaired natural killer cell mediated cytotoxicity |
J:280182
|
|
increased immature NK cell number |
J:280182
|
|
normal
mortality/aging |
J:280182
|
Syktm1.1Nns/Syktm1.1Nns
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/10 * CBA/Ca
|
abnormal blood vessel morphology |
J:181715
|
|
abnormal lymphatic vessel morphology |
J:181715
|
|
edema |
J:181715
|
|
normal
mortality/aging |
J:181715
|
Syktm1.1Nns/Syktm1.1Nns
Tg(Tie1-cre)9Ref/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
|
abnormal lymphatic vessel morphology |
J:181715
|
|
normal
mortality/aging |
J:181715
|
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
|
decreased pro-B cell number |
J:137719
|
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL * CBA
|
normal
immune system phenotype |
J:137719
|
Tg(JAK2*V617F)FF1Rsko/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal bone marrow morphology |
J:134364
|
|
abnormal common myeloid progenitor cell morphology |
J:134364
|
|
abnormal erythropoiesis |
J:134364
|
|
abnormal megakaryocyte progenitor cell morphology |
J:134364
|
|
abnormal myelopoiesis |
J:134364
|
|
abnormal spleen morphology |
J:134364
|
|
decreased B cell number |
J:134364
|
|
decreased hemoglobin content |
J:134364
|
|
decreased T cell number |
J:134364
|
|
enlarged spleen |
J:134364
|
|
extramedullary hematopoiesis |
J:134364
|
|
increased bone marrow cell number |
J:134364
|
|
increased erythroid progenitor cell number |
J:134364
|
|
increased megakaryocyte cell number |
J:134364
|
|
increased neutrophil cell number |
J:134364
|
|
myelofibrosis |
J:134364
|
|
spleen fibrosis |
J:134364
|
|
thrombocytosis |
J:134364
|
Tg(Kit*D814V)1Roer/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
neonatal lethality |
J:169611
|
Tg(Kit*D814V)3Roer/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
neonatal lethality |
J:169611
|
Trp53tm1Tyj/Trp53tm1Tyj
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca
|
abnormal interleukin secretion |
J:305794
|
Trp53tm1Tyj/Trp53tm1Tyj
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca
|
normal
immune system phenotype |
J:305794
|
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca
|
abnormal acute inflammation |
J:282740
|
|
abnormal gut-associated lymphoid tissue morphology |
J:282740
|
|
abnormal interleukin secretion |
J:282740
|
|
abnormal lymphocyte physiology |
J:282740
|
|
abnormal lymphopoiesis |
J:282740
|
|
decreased interferon-gamma secretion |
J:282740
|
|
decreased interleukin-5 secretion |
J:282740
|
|
decreased interleukin-12 secretion |
J:282740
|
|
decreased lymphocyte cell number |
J:282740
|
|
decreased Peyer's patch number |
J:282740
|
|
increased susceptibility to bacterial infection |
J:282740
|
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zbtb17tm1Cksn Commd10Tg(Vav1-icre)A2Kio
|
arrested T cell differentiation |
J:170508
|
|
decreased DN1 thymic pro-T cell number |
J:170508
|
|
decreased DN2 thymocyte number |
J:170508
|
|
decreased DN3 thymocyte number |
J:170508
|
|
decreased double-negative T cell number |
J:170508
|
|
decreased gamma-delta T cell number |
J:170508
|
|
decreased T cell number |
J:170508
|
|
decreased thymocyte number |
J:170508
|
|
increased T cell apoptosis |
J:170508
|
|
thymus hypoplasia |
J:170508
|
Zbtb38em1Dbhat/Zbtb38em1Dbhat
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
|
normal
immune system phenotype |
J:296556
|
Zfp318tm1.1Jhws/Zfp318tm1.1Jhws
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zfp318tm1.1Jhws TgVav1-creA2Kio
|
decreased IgD level |
J:215815
|
|
decreased transitional stage T2 B cell number |
J:215815
|
|
increased IgM level |
J:215815
|
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