Ino80 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ino80
INO80 complex subunit
MGI:1915392

33 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ino80^tm1.1Jland/Ino80^tm1.1Jland B6.129(C3)-Ino80^tm1.1Jland/J	no abnormal phenotype detected	J:101977
Ino80^tm1.1Schg/Ino80⁺ involves: C57BL/6J	decreased body size	J:221224
Ino80^tm1.1Schg/Ino80⁺ involves: C57BL/6J	limb grasping	J:221224
Ino80^tm1.1Schg/Ino80^tm1.1Schg involves: C57BL/6J	abnormal embryo development	J:221224
	embryonic growth retardation	J:221224
	embryonic lethality, incomplete penetrance	J:221224
	preweaning lethality, complete penetrance	J:221224
Ino80^tm1.2Jland/Ino80^tm1.2Jland B6.129(C)-Ino80^tm1.2Jland	absent anterior visceral endoderm	J:229516
	absent distal visceral endoderm	J:229516
	embryonic lethality between implantation and placentation, complete penetrance	J:229516
Ino80^{tm1a(EUCOMM)Hmgu}/Ino80⁺ C57BL/6N-Ino80^{tm1a(EUCOMM)Hmgu}/Ics	abnormal seminal vesicle morphology	J:211773
	abnormal vocalization	J:211773
	decreased exploration in new environment	J:211773
	decreased locomotor activity	J:211773
	increased aggression	J:211773
	prolonged QRS complex duration	J:211773
Ino80^{tm1a(EUCOMM)Hmgu}/Ino80^{tm1a(EUCOMM)Hmgu} C57BL/6N-Ino80^{tm1a(EUCOMM)Hmgu}/Ics	preweaning lethality, complete penetrance	J:211773
Ino80^{tm1b(EUCOMM)Hmgu}/Ino80^{tm1b(EUCOMM)Hmgu} C57BL/6N-Ino80^{tm1b(EUCOMM)Hmgu}/Ics	preweaning lethality, incomplete penetrance	J:211773
Ino80^tm1Schg/Ino80^tm1Schg Tg(CAG-cre/Esr1)5Amc/0 involves: C57BL/6 CBA	abnormal cell cycle	J:221224
	abnormal cell physiology	J:221224
	abnormal DNA repair	J:221224
	abnormal DNA replication	J:221224
	abnormal double-strand DNA break repair	J:221224
	abnormal response to radiation	J:221224
	abnormal telomere morphology	J:221224
	normal cellular phenotype	J:221224
	decreased body weight	J:221224
	decreased fibroblast proliferation	J:221224
	early cellular replicative senescence	J:221224
	increased cellular sensitivity to alkylating agents	J:221224
	increased cellular sensitivity to hydroxyurea	J:221224
	increased cellular sensitivity to ultraviolet irradiation	J:221224
	normal neoplasm	J:221224
	premature death	J:221224

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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