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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Dusp6
dual specificity phosphatase 6
MGI:1914853
27 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Dusp6tm1Jmol/Dusp6tm1Jmol
involves: 129 * C57BL/6
abnormal heart development J:142966
abnormal muscle physiology J:190460
normal cardiovascular system phenotype J:142966
decreased myocardial infarct size J:142966
decreased response of heart to induced stress J:142966
decreased sensitivity to induced cell death J:142966
heart hyperplasia J:142966
increased heart weight J:142966
increased satellite cell number J:190460
increased spleen weight J:142966
normal muscle phenotype J:190460
Dusp6tm1Sms/Dusp6+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal auditory brainstem response J:117073
abnormal cranium morphology J:117073
abnormal middle ear ossicle morphology J:117073
abnormal otic capsule morphology J:117073
postnatal lethality J:117073
premature coronal suture closure J:117073
Dusp6tm1Sms/Dusp6tm1Sms
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal auditory brainstem response J:117073
abnormal cranium morphology J:117073
abnormal long bone epiphyseal ossification zone morphology J:117073
abnormal long bone hypertrophic chondrocyte zone J:117073
abnormal middle ear ossicle morphology J:117073
abnormal otic capsule morphology J:117073
decreased body weight J:117073
delayed bone ossification J:117073
postnatal lethality J:117073
premature coronal suture closure J:117073
Tg(Myh6-tTA)55Rbns/0
Tg(tetO-Dusp6)1Jmol/0
involves: FVB/N
abnormal respiratory system physiology J:124903
cardiac fibrosis J:124903
cardiac hypertrophy J:124903
decreased cardiac muscle contractility J:124903
increased cardiomyocyte apoptosis J:124903
increased myocardial fiber size J:124903

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory