Pole4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pole4
polymerase (DNA-directed), epsilon 4 (p12 subunit)
MGI:1914229

62 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pole4^{tm1(KOMP)Vlcg}/Pole4^{tm1(KOMP)Vlcg} involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac * FVB/N	abnormal B cell differentiation	J:261973
	abnormal cell cycle	J:261973
	abnormal craniofacial morphology	J:261973
	abnormal DNA replication	J:261973
	abnormal fourth ventricle morphology	J:261973
	abnormal gait	J:261973
	abnormal mesenteric lymph node morphology	J:261973
	abnormal pelvic girdle bone morphology	J:261973
	abnormal roof plate morphology	J:261973
	abnormal spleen B cell follicle morphology	J:261973
	abnormal T cell differentiation	J:261973
	abnormal thymus morphology	J:261973
	absent thymus cortex	J:261973
	anemia	J:261973
	arrested B cell differentiation	J:261973
	ataxia	J:261973
	athymia	J:261973
	belly spot	J:261973
	caudal vertebral fusion	J:261973
	chromosomal instability	J:261973
	curly tail	J:261973
	decreased B cell number	J:261973
	decreased body length	J:261973
	decreased body weight	J:261973
	decreased brain weight	J:261973
	decreased embryo size	J:261973
	decreased embryo weight	J:261973
	decreased fetal size	J:261973
	decreased fetal weight	J:261973
	decreased fibroblast proliferation	J:261973
	decreased hematopoietic stem cell number	J:261973
	decreased leukocyte cell number	J:261973
	decreased litter size	J:261973
	decreased lymphocyte cell number	J:261973
	decreased male germ cell number	J:261973
	decreased single-positive T cell number	J:261973
	decreased spleen weight	J:261973
	impaired coordination	J:261973
	increased cellular sensitivity to hydroxyurea	J:261973
	increased double-negative T cell number	J:261973
	increased embryonic tissue cell apoptosis	J:261973
	increased forebrain apoptosis	J:261973
	increased granulocyte number	J:261973
	increased hematopoietic stem cell number	J:261973
	increased lymphoma incidence	J:261973
	increased monocyte cell number	J:261973
	increased T cell derived lymphoma incidence	J:261973
	induced chromosome breakage	J:261973
	kinked tail	J:261973
	lethality throughout fetal growth and development, incomplete penetrance	J:261973
	postnatal growth retardation	J:261973
	prenatal growth retardation	J:261973
	prominent forehead	J:261973
	reduced cerebellar foliation	J:261973
	reduced fertility	J:261973
	short mandible	J:261973
	short tibia	J:261973
	small cerebellum	J:261973
	small spleen	J:261973
	thrombocytosis	J:261973
Pole4^{tm1(KOMP)Vlcg}/Pole4^{tm1(KOMP)Vlcg} involves: C57BL/6J * C57BL/6NTac	abnormal DNA replication	J:261973
	abnormal embryo development	J:261973
	embryonic lethality during organogenesis, incomplete penetrance	J:261973

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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