Plin5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plin5
perilipin 5
MGI:1914218

33 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Plin5^{tm1e(KOMP)Wtsi}/Plin5^{tm1e(KOMP)Wtsi} involves: C57BL/6N	abnormal carbohydrate metabolism	J:221539
	abnormal ceramide level	J:221539
	abnormal sphingomyelin level	J:221539
	decreased adipocyte glucose uptake	J:221539
	decreased cardiac muscle triglyceride level	J:221539
	decreased fatty acid oxidation	J:221539
	decreased skeletal muscle glycogen level	J:221539
	decreased skeletal muscle triglyceride level	J:221539
	enhanced lipolysis	J:221539
	improved glucose tolerance	J:221539
	increased fatty acid oxidation	J:221539
	increased insulin sensitivity	J:221539
	increased respiratory quotient	J:221539
	insulin resistance	J:221539
Plin5^tm1Macl/Plin5^tm1Macl involves: 129S6/SvEvTac * C57BL/6JBomTac	abnormal cardiovascular system physiology	J:286482
	abnormal heart morphology	J:286482
	abnormal response to cardiac infarction	J:286482
	decreased cardiac muscle contractility	J:286482
	decreased cardiac muscle triglyceride level	J:286482
	decreased fatty acid oxidation	J:286482
	increased cardiac muscle cell glucose uptake	J:286482
	increased response of heart to induced stress	J:286482
	increased susceptibility to induced morbidity/mortality	J:286482
Plin5^tm1Tosu/Plin5^tm1Tosu involves: C57BL/6JJcl	abnormal heart ventricle morphology	J:188390
	abnormal lipid level	J:188390
	decreased cardiac muscle contractility	J:188390
	decreased cardiac muscle triglyceride level	J:188390
	decreased fatty acids level	J:188390
	decreased liver free fatty acids level	J:188390
	decreased liver triglyceride level	J:188390
	decreased triglyceride level	J:188390
	hyperactivity	J:188390
	increased circulating free fatty acids level	J:188390
	increased fatty acid oxidation	J:188390
	increased liver free fatty acids level	J:188390
	increased liver triglyceride level	J:188390
	increased oxygen consumption	J:188390
	oxidative stress	J:188390

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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