Lrrk2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lrrk2
leucine-rich repeat kinase 2
MGI:1913975

60 phenotypes from 18 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lrrk2^tm1.1Cai/Lrrk2^tm1.1Cai involves: 129X1/SvJ * C57BL/6	microgliosis	J:156512
Lrrk2^tm1.1Cai/Lrrk2^tm1.1Cai involves: 129X1/SvJ * C57BL/6	normal nervous system phenotype	J:156512
Lrrk2^tm1.1Cai/Lrrk2^tm1.1Cai involves: 129X1/SvJ * C57BL/6J * FVB/N	abnormal axon morphology	J:154755
	abnormal neurite morphology	J:154755
Lrrk2^tm1.1Dlbe/Lrrk2⁺ C57BL/6NTac-Lrrk2^tm1.1Dlbe	increased excitatory postsynaptic current frequency	J:234639
Lrrk2^tm1.1Dlbe/Lrrk2^tm1.1Dlbe C57BL/6NTac-Lrrk2^tm1.1Dlbe	abnormal dendritic spine morphology	J:234639
	abnormal excitatory postsynaptic current amplitude	J:234639
	abnormal excitatory postsynaptic currents	J:234639
	increased excitatory postsynaptic current frequency	J:234639
Lrrk2^tm1.1Hlme/Lrrk2⁺ involves: C57BL/6 * C57BL/6J	abnormal dopamine level	J:223350
	abnormal mitochondrial crista morphology	J:223350
	abnormal mitochondrial morphology	J:223350
	abnormal mitochondrial shape	J:223350
	abnormal motor coordination/balance	J:223350
	abnormal synaptic dopamine release	J:223350
	tau protein deposits	J:223350
Lrrk2^tm1.1Hlme/Lrrk2^tm1.1Hlme involves: C57BL/6 * C57BL/6J	abnormal dopamine level	J:223350
	abnormal lipid level	J:223350
	abnormal locomotor behavior	J:223350
	abnormal mitochondrial crista morphology	J:223350
	abnormal mitochondrial fission	J:223350
	abnormal mitochondrial morphology	J:223350
	abnormal mitochondrial shape	J:223350
	abnormal synaptic dopamine release	J:223350
	normal cardiovascular system phenotype	J:223350
	decreased mitochondrial number	J:223350
	dilated mitochondrion	J:223350
	enhanced coordination	J:223350
	increased locomotor activity	J:223350
	normal renal/urinary system phenotype	J:223350
	normal respiratory system phenotype	J:223350
	tau protein deposits	J:223350
Lrrk2^tm1.1Mjff/Lrrk2^tm1.1Mjff C57BL/6-Lrrk2^tm1.1Mjff/J	normal skeleton phenotype	J:208677
Lrrk2^tm1.1Npa/Lrrk2^tm1.1Npa either: B6.C-Lrrk2^tm1.1Npa or (involves: BALB/c * C57BL/6J)	normal behavior/neurological phenotype	J:176679
	normal cardiovascular system phenotype	J:176679
	increased systemic arterial diastolic blood pressure	J:176679
	normal nervous system phenotype	J:176679
Lrrk2^tm1.1Shn/Lrrk2^tm1.1Shn involves: 129 * C57BL/6	abnormal action potential	J:151944
	abnormal adrenal gland secretion	J:151944
	abnormal response/metabolism to endogenous compounds	J:151944
	decreased physiological sensitivity to xenobiotic	J:151944
	impaired behavioral response to addictive substance	J:151944
	impaired behavioral response to xenobiotic	J:151944
	normal nervous system phenotype	J:151944
Lrrk2^tm1.2Npa/Lrrk2^tm1.2Npa involves: BALB/c * C57BL/6J	abnormal kidney morphology	J:176679
	abnormal proximal convoluted tubule morphology	J:176679
	abnormal type II pneumocyte morphology	J:176679
	normal behavior/neurological phenotype	J:176679
	normal cardiovascular system phenotype	J:176679
	dilated renal tubule	J:176679
	increased kidney weight	J:176679
	increased systemic arterial diastolic blood pressure	J:176679
	increased urine protein level	J:176679
	lipofuscinosis	J:176679
	normal nervous system phenotype	J:176679
Lrrk2^tm1Arte/Lrrk2^tm1Arte involves: C57BL/6N	abnormal dendrite morphology	J:206546
	abnormal hippocampal mossy fiber morphology	J:206546
	increased neuronal precursor cell number	J:206546
Lrrk2^tm1Mjfa/Lrrk2^tm1Mjfa involves: C57BL/6	abnormal axon extension	J:172418
Lrrk2^tm1Mjfa/Lrrk2^tm1Mjfa involves: C57BL/6	abnormal neurite morphology	J:172418
Lrrk2^tm1Tmd/Lrrk2^tm1Tmd involves: 129S/SvEv * C57BL/6	alopecia	J:157100
	increased grooming behavior	J:157100
	preweaning lethality, incomplete penetrance	J:157100
Lrrk2^tm2.1Dlbe/Lrrk2^tm2.1Dlbe C57BL/6NTac-Lrrk2^tm2.1Dlbe	normal nervous system phenotype	J:234639
Lrrk2^tm2.1Npa/Lrrk2^tm2.1Npa involves: BALB/c * C57BL/6J	abnormal kidney morphology	J:176679
	abnormal proximal convoluted tubule morphology	J:176679
	normal cardiovascular system phenotype	J:176679
	dilated renal tubule	J:176679
	increased kidney weight	J:176679
	lipofuscinosis	J:176679
	normal respiratory system phenotype	J:176679
Lrrk2^tm2.1Shn/Lrrk2^tm2.1Shn involves: 129 * C57BL/6	abnormal autophagy	J:160542
	abnormal kidney morphology	J:160542
	decreased kidney weight	J:160542
	granular kidney	J:160542
	increased kidney apoptosis	J:160542
	increased renal glomerulus apoptosis	J:160542
	increased renal tubule apoptosis	J:160542
	kidney atrophy	J:160542
	kidney inflammation	J:160542
	lipofuscinosis	J:160542
	normal nervous system phenotype	J:160542
	small kidney	J:160542
Lrrk2^tm2Arte/Lrrk2^tm2Arte Not Specified	no abnormal phenotype detected	J:211935
Lrrk2^tm2Mjfa/Lrrk2^tm2Mjfa Not Specified	normal nervous system phenotype	J:172418
Lrrk2^tm3.1Mjfa/Lrrk2^tm3.1Mjfa involves: C57BL/6	no abnormal phenotype detected	J:101977
Lrrk2^tm3.1Shn/Lrrk2^tm3.1Shn involves: 129 * C57BL/6	abnormal kidney morphology	J:160542
	decreased kidney weight	J:160542
	granular kidney	J:160542
	kidney atrophy	J:160542
	normal nervous system phenotype	J:160542
	small kidney	J:160542
Lrrk2^tm4.1Arte/Lrrk2⁺ C57BL/6-Lrrk2^tm4.1Arte/Tac	abnormal brain interneuron morphology	J:312767
Lrrk2^tm4.1Arte/Lrrk2⁺ C57BL/6-Lrrk2^tm4.1Arte/Tac	abnormal dorsal striatum morphology	J:312767

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23