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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Crbn
cereblon
MGI:1913277
38 phenotypes from 5 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Crbntm1.1Ble/Crbntm1.1Ble
involves: C57BL/6 		abnormal bone marrow hematopoietic cell morphology J:267091
anophthalmia J:267091
decreased B cell number J:267091
decreased common myeloid progenitor cell number J:267091
decreased granulocyte monocyte progenitor cell number J:267091
decreased granulocyte number J:267091
decreased leukocyte cell number J:267091
decreased T cell number J:267091
increased physiological sensitivity to xenobiotic J:267091
prenatal lethality, incomplete penetrance J:267091
thrombocytopenia J:267091
Crbntm1.1Jjh/Crbntm1.1Jjh
B6(Cg)-Crbntm1.1Jjh/J 		abnormal long-term spatial reference memory J:259276
impaired contextual conditioning behavior J:259276
impaired spatial learning J:259276
Crbntm1.1Jjh/Crbntm1.1Jjh
Tg(Camk2a-cre)T29-1Stl/0
involves: C57BL/6 		normal behavior/neurological phenotype J:179427
impaired contextual conditioning behavior J:179427
Crbntm1.2Jjh/Crbntm1.2Jjh
involves: C57BL/6 		abnormal long-term spatial reference memory J:259276
abnormal synapse morphology J:259276
normal behavior/neurological phenotype J:179427, J:259276
impaired contextual conditioning behavior J:179427, J:259276
impaired spatial learning J:259276
normal nervous system phenotype J:259276
reduced long-term potentiation J:259276
Crbntm1b(KOMP)Wtsi/Crbntm1b(KOMP)Wtsi
C57BL/6N-Crbntm1b(KOMP)Wtsi/Ucd 		abnormal cecum morphology J:211773
abnormal eye morphology J:211773
abnormal heart morphology J:211773
absent optic nerve J:211773
decreased prepulse inhibition J:211773
enlarged heart J:211773
Crbntm1Csp/Crbntm1Csp
B6N.Cg-Crbntm1Csp 		abnormal liver morphology J:208570
normal behavior/neurological phenotype J:208570
decreased body weight J:208570
decreased circulating free fatty acids level J:208570
decreased circulating glucose level J:208570
decreased circulating insulin level J:208570
decreased circulating leptin level J:208570
decreased epididymal fat pad weight J:208570
decreased liver triglyceride level J:208570
decreased liver weight J:208570
decreased susceptibility to diet-induced hepatic steatosis J:208570
decreased susceptibility to diet-induced obesity J:208570
improved glucose tolerance J:208570
increased insulin sensitivity J:208570
small liver J:208570
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory