Trem2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Trem2
triggering receptor expressed on myeloid cells 2
MGI:1913150

16 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Trem2^em2Bwef/Trem2⁺ involves: C57BL/6J * DBA/2J * FVB/N	decreased macrophage cell number	J:242126
Trem2^em2Bwef/Trem2^em2Bwef involves: C57BL/6J * DBA/2J * FVB/N	abnormal blood volume	J:242126
	abnormal glucose homeostasis	J:242126
	decreased macrophage cell number	J:242126
	decreased macrophage proliferation	J:242126
	decreased microglial cell activation	J:242126
	impaired macrophage phagocytosis	J:242126
	increased circulating interleukin-6 level	J:242126
	increased circulating tumor necrosis factor level	J:242126
	increased macrophage apoptosis	J:242126
	increased susceptibility to endotoxin shock	J:242126
Trem2^{tm1(KOMP)Vlcg}/Trem2^{tm1(KOMP)Vlcg} C57BL/6N-Trem2^{tm1(KOMP)Vlcg}	abnormal cell cycle checkpoint function	J:239381
	abnormal glial cell apoptosis	J:239381
	abnormal microglial cell physiology	J:239381
	decreased microglial cell activation	J:239381
Trem2^tm1Cln/Trem2^tm1Cln B6.129P2-Trem2^tm1Cln	abnormal interferon level	J:138057
	abnormal interleukin level	J:138057
	abnormal tumor necrosis factor level	J:138057

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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