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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Actn4
actinin alpha 4
MGI:1890773
64 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Actn4tm1a(EUCOMM)Wtsi/Actn4+
C57BL/6N-Actn4tm1a(EUCOMM)Wtsi/Wtsi
abnormal retina morphology J:211773
increased heart weight J:211773
Actn4tm1a(EUCOMM)Wtsi/Actn4tm1a(EUCOMM)Wtsi
C57BL/6N-Actn4tm1a(EUCOMM)Wtsi/Wtsi
abnormal atrioventricular cushion morphology J:239583
abnormal coronary sinus connection J:239583
abnormal ductus venosus valve morphology J:239583
abnormal ductus venosus valve topology J:239583
abnormal eye muscle morphology J:239583
abnormal forebrain morphology J:239583
abnormal hypoglossal canal morphology J:239583
abnormal hypoglossal nerve topology J:239583
abnormal inferior vena cava morphology J:239583
abnormal infrahyoid muscle connection J:239583
abnormal intestine placement J:239583
abnormal lens epithelium morphology J:239583
abnormal Mullerian duct morphology J:239583
abnormal optic cup morphology J:239583
abnormal vein morphology J:239583
absent ductus venosus valve J:239583
absent hypoglossal canal J:239583
absent hypoglossal nerve J:239583
absent stapedial artery J:239583
absent superior cervical ganglion J:239583
arteriovenous malformation J:239583
biliary cyst J:239583
blood in lymph vessels J:239583
dilated liver sinusoidal space J:239583
double outlet right ventricle J:239583
embryo tumor J:239583
hemopericardium J:239583
heterochrony J:239583
increased trigeminal neuroma incidence J:239583
multiple persisting craniopharyngeal ducts J:239583
muscular ventricular septal defect J:239583
overriding aortic valve J:239583
perimembraneous ventricular septal defect J:239583
persistent dorsal ophthalmic artery J:239583
preweaning lethality, incomplete penetrance J:211773
short snout J:239583
small hypoglossal canal J:239583
small superior cervical ganglion J:239583
subcutaneous edema J:239583
thin hypoglossal nerve J:239583
Actn4tm1Mrpk/Actn4tm1Mrpk
involves: 129 * C57BL/6
abnormal blood urea nitrogen level J:83911
abnormal glomerular capillary morphology J:83911
abnormal lymphocyte chemotaxis J:83911
abnormal podocyte adhesion J:118122
abnormal renal glomerulus basement membrane morphology J:83911
albuminuria J:83911, J:118122
cortical renal glomerulopathies J:83911
decreased podocyte number J:118122
detached podocyte J:118122
dilated renal tubule J:83911
glomerulosclerosis J:83911
increased urine microalbumin level J:83911
increased urine protein level J:90755
kidney failure J:83911
pale kidney J:83911
perinatal lethality, incomplete penetrance J:83911
podocyte foot process effacement J:83911
postnatal growth retardation J:83911
premature death J:83911
renal cast J:83911
small kidney J:83911
weight loss J:83911

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory