Vps35 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Vps35
VPS35 retromer complex component
MGI:1890467

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cx3cr1^{tm2.1(cre/ERT2)Litt}/Cx3cr1⁺ Vps35^{Gt(RRK261)Byg}/Vps35^{Gt(RRK261)Byg} involves: 129P2/OlaHsd * C57BL/6	decreased cerebral infarct size	J:292365
	decreased interleukin-1 beta secretion	J:292365
	decreased interleukin-6 secretion	J:292365
	decreased neuron apoptosis	J:292365
	decreased susceptibility to induced morbidity/mortality	J:292365
	decreased tumor necrosis factor secretion	J:292365
	increased interleukin-4 secretion	J:292365
	increased interleukin-10 secretion	J:292365
	increased macrophage cell number	J:292365
	increased transforming growth factor beta level	J:292365
	microgliosis	J:292365
Vps35^{Gt(RRK261)Byg}/Vps35⁺ Tg(APPSWE)2576Kha/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal excitatory postsynaptic potential	J:178937
	abnormal miniature excitatory postsynaptic currents	J:178937
	abnormal spatial learning	J:178937
	amyloid beta deposits	J:178937
	decreased post-tetanic potentiation	J:178937
	impaired synaptic plasticity	J:178937
	normal nervous system phenotype	J:178937
	reduced AMPA-mediated synaptic currents	J:178937
	reduced long-term potentiation	J:178937
	reduced NMDA-mediated synaptic currents	J:178937

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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