Vps35 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Vps35
VPS35 retromer complex component
MGI:1890467

31 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Vps35^em1(IMPC)H/Vps35⁺ C57BL/6N-Vps35^em1(IMPC)H/H	abnormal gait	J:211773
Vps35^em1(IMPC)H/Vps35⁺ C57BL/6N-Vps35^em1(IMPC)H/H	abnormal retina morphology	J:211773
Vps35^em1(IMPC)H/Vps35^em1(IMPC)H C57BL/6N-Vps35^em1(IMPC)H/H	preweaning lethality, complete penetrance	J:211773
Vps35^{Gt(RRK261)Byg}/Vps35⁺ B6.129P2-Vps35^{Gt(RRK261)Byg}	abnormal dopaminergic neuron morphology	J:225806
	abnormal lysosome morphology	J:225806
	alpha-synuclein inclusion body	J:225806
	decreased dopamine level	J:225806
	decreased locomotor activity	J:225806
	decreased vertical activity	J:225806
	loss of dopaminergic neurons	J:225806
Vps35^{Gt(RRK261)Byg}/Vps35^{Gt(RRK261)Byg} B6.129P2-Vps35^{Gt(RRK261)Byg}	embryonic lethality, complete penetrance	J:178937
Vps35^tm1.1Hckn/Vps35^tm1.1Hckn Tg(Vil1-cre/ERT2)23Syr/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal small intestinal crypt cell proliferation	J:223191
	normal digestive/alimentary phenotype	J:223191
Vps35^tm1.1Hlw/Vps35⁺ involves: 129S/SvEv * C57BL/6J	abnormal mitochondrial shape	J:329507
	abnormal substantia nigra pars compacta morphology	J:329507
	bradykinesia	J:329507
	decreased locomotor activity	J:329507
	decreased mitochondrial size	J:329507
	normal nervous system phenotype	J:329507
	oxidative stress	J:329507
	slow movement	J:329507
Vps35^tm1.1Mjff/Vps35⁺ B6.Cg-Vps35^tm1.1Mjff	abnormal nervous system dopamine level	J:274797
Vps35^tm1.1Mjff/Vps35^tm1.1Mjff B6.Cg-Vps35^tm1.1Mjff	abnormal axon morphology	J:303283
	abnormal dopaminergic neuron morphology	J:303283
	abnormal mitochondrial physiology	J:303283
	abnormal mitochondrial shape	J:303283
	abnormal nervous system dopamine level	J:274797
	alpha-synuclein inclusion body	J:303283
	astrocytosis	J:303283
	normal behavior/neurological phenotype	J:303283
	decreased dopaminergic neuron number	J:303283
	decreased locomotor activity	J:303283
	impaired coordination	J:303283
	lipofuscinosis	J:303283
	microgliosis	J:303283
	neurodegeneration	J:303283
Vps35^tm1.2Mjff/Vps35⁺ involves: C57BL/6	no abnormal phenotype detected	J:101977

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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