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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lmx1a
LIM homeobox transcription factor 1 alpha
MGI:1888519
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lmx1adr-J/Lmx1adr-J
Lmx1btm1Rjo/Lmx1btm1Rjo
involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6 		abnormal fourth ventricle morphology J:152673
Lmx1adr-J/Lmx1adr-J
Lmx1btm1Rjo/Lmx1btm1Zfc
Tg(Lmx1a-cre)1Kjmi/0
involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6 		abnormal cerebellum development J:152673
abnormal cerebellum morphology J:152673
abnormal fourth ventricle morphology J:152673
small cerebellum J:152673
Lmx1atm1Ics/Lmx1a+
Lmx1btm1Rjo/Lmx1b+
involves: 129S7/SvEvBrd * C57BL/6J 		decreased dopaminergic neuron number J:175535
Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1b+
involves: 129S7/SvEvBrd * C57BL/6J 		decreased dopaminergic neuron number J:175535
Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1btm1Rjo
involves: 129S7/SvEvBrd * C57BL/6J 		embryonic lethality J:175535
Lmx1atm1Tpe/Lmx1atm1Tpe
Lmx1btm1Zfc/Lmx1btm1Zfc
Slc6a3tm1(cre)Lrsn/Slc6a3+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		abnormal autophagy J:222854
abnormal innervation J:222854
abnormal lysosome morphology J:222854
abnormal lysosome physiology J:222854
abnormal synapse morphology J:222854
abnormal synaptic bouton morphology J:222854
abnormal synaptic vesicle number J:222854
decreased dopamine level J:222854
enhanced long-term potentiation J:222854
impaired coordination J:222854
impaired olfaction J:222854
impaired short-term object recognition memory J:222854
increased locomotor activity J:222854
neurodegeneration J:222854
Lmx1atm1Tpe/Lmx1atm1Tpe
Lmx1btm1Zfc/Lmx1btm1Zfc
Tg(Slc6a3-cre/ERT2)1Span/0
involves: 129S7/SvEvBrd * C57BL/6 		abnormal synaptic bouton morphology J:222854
decreased dopamine level J:222854
neurodegeneration J:222854
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory