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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mefv
Mediterranean fever
MGI:1859396
45 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il1r1tm1Roml/Il1r1tm1Roml
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 		normal immune system phenotype J:172117
increased interleukin-1 beta secretion J:172117
Mefvtm3.1(MEFV)Chae/Mefvtm3.1(MEFV)Chae
B6.129S6-Mefvtm3.1(MEFV)Chae 		arthritis J:172117
cachexia J:172117
decreased body weight J:172117
dermatitis J:172117
increased inflammatory response J:172117
increased leukocyte cell number J:172117
postnatal growth retardation J:172117
Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
B6.129S6-Mefvtm4.1(MEFV)Chae 		arthritis J:172117
cachexia J:172117
decreased body weight J:172117
dermatitis J:172117
increased inflammatory response J:172117
increased leukocyte cell number J:172117
postnatal growth retardation J:172117
Mefvtm5.1(MEFV)Chae/Mefv+
B6.129S6-Mefvtm5.1(MEFV)Chae 		no abnormal phenotype detected J:172117
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
B6.129S6-Mefvtm5.1(MEFV)Chae 		abnormal cytokine secretion J:172117
abnormal spleen germinal center morphology J:172117
anemia J:172117
arthritis J:172117
cachexia J:172117
decreased B cell number J:172117
decreased body size J:172117
decreased body weight J:172117
decreased interleukin-3 secretion J:172117
decreased lymphocyte cell number J:172117
decreased T cell number J:172117
dermatitis J:172117
enlarged lymph nodes J:172117
enlarged spleen J:172117
increased circulating interleukin-1 beta level J:172117
increased circulating interleukin-6 level J:172117
increased circulating tumor necrosis factor level J:172117
increased granulocyte number J:172117
increased inflammatory response J:172117
increased interferon-gamma secretion J:172117
increased interleukin-1 alpha secretion J:172117
increased interleukin-1 beta secretion J:172117
increased interleukin-2 secretion J:172117
increased interleukin-4 secretion J:172117
increased interleukin-5 secretion J:172117
increased interleukin-9 secretion J:172117
increased interleukin-10 secretion J:172117
increased interleukin-12 secretion J:172117
increased interleukin-12b secretion J:172117
increased interleukin-13 secretion J:172117
increased interleukin-17 secretion J:172117
increased leukocyte cell number J:172117
increased macrophage cell number J:172117
increased monocyte cell number J:172117
increased neutrophil cell number J:172117
joint inflammation J:172117
liver inflammation J:172117
postnatal growth retardation J:172117
postnatal lethality, complete penetrance J:172117
scaly skin J:172117
skin inflammation J:172117
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Nlrp3tm1Tsc/Nlrp3tm1Tsc
involves: 129S6/SvEvTac * C57BL/6 		decreased body weight J:172117
increased inflammatory response J:172117
increased interleukin-1 beta secretion J:172117
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Pycardtm1Tno/Pycardtm1Tno
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		decreased interleukin-1 beta secretion J:172117
normal growth/size/body region phenotype J:172117
normal immune system phenotype J:172117
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Rag1tm1Mom/Rag1tm1Mom
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal cytokine secretion J:172117
decreased body weight J:172117
increased circulating interleukin-1 beta level J:172117
increased circulating interleukin-6 level J:172117
increased circulating tumor necrosis factor level J:172117
increased inflammatory response J:172117
increased interferon-gamma secretion J:172117
increased interleukin-1 beta secretion J:172117
increased interleukin-2 secretion J:172117
increased interleukin-4 secretion J:172117
increased interleukin-5 secretion J:172117
increased interleukin-9 secretion J:172117
increased interleukin-10 secretion J:172117
increased interleukin-12 secretion J:172117
increased interleukin-13 secretion J:172117
increased interleukin-17 secretion J:172117
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory