60 phenotypes from 8 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dll4tm1Frad/Dll4+ Isl1tm1(cre)Tmj/Isl1+ involves: 129S1/Sv * 129X1/SvJ	abnormal cardiac outflow tract development	J:308916
	abnormal pulmonary valve morphology	J:308916
	double outlet right ventricle	J:308916
	overriding aortic valve	J:308916
	ventricular septal defect	J:308916
Dll4tm1Frad/Dll4tm1Frad Foxn1tm3(cre)Nrm/Foxn1+ B6.Cg-Dll4tm1Frad Foxn1tm3(cre)Nrm	abnormal T cell differentiation	J:143472
	abnormal thymus cell ratio	J:143472
	decreased CD4-positive, alpha-beta T cell number	J:143472
	decreased CD8-positive, alpha-beta T cell number	J:143472
	decreased double-positive T cell number	J:143472
	decreased thymocyte number	J:143472
	increased immature B cell number	J:143472
Dll4tm1Frad/Dll4tm1Frad Tg(Mx1-cre)1Cgn/0 B6.Cg-Dll4tm1Frad Tg(Mx1-cre)1Cgn	normal immune system phenotype	J:143472
Dll4tm1Grid/Dll4+ either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)	abnormal anterior cardinal vein morphology	J:93125
	abnormal capillary morphology	J:93125
	abnormal common cardinal vein morphology	J:93125
	abnormal dorsal aorta morphology	J:93125
	abnormal vascular regression	J:93125
	abnormal vitelline vascular remodeling	J:93125
	arteriovenous malformation	J:93125
	blood vessel atresia	J:93125
	embryonic growth retardation	J:93125
	pericardial effusion	J:93125
	preweaning lethality, complete penetrance	J:93125
Dll4tm1Jrt/Dll4+ involves: 129S1/Sv * 129X1/SvJ	embryonic lethality during organogenesis, complete penetrance	J:93157
Dll4tm1Jrt/Dll4+ involves: 129S1/Sv * 129X1/SvJ * ICR	abnormal cardinal vein morphology	J:93157
	abnormal dorsal aorta morphology	J:93157
	abnormal pericardial cavity morphology	J:93157
	abnormal placenta vasculature	J:93157
	abnormal umbilical artery morphology	J:93157
	abnormal vitelline vasculature morphology	J:93157
	embryonic growth retardation	J:93157
	poor circulation	J:93157
	prenatal lethality, incomplete penetrance	J:93157
Dll4tm1Jrt/Dll4tm1Jrt involves: 129S1/Sv * 129X1/SvJ * ICR	abnormal anterior cardinal vein morphology	J:93157
	abnormal artery morphology	J:93157
	abnormal dorsal aorta morphology	J:93157
	abnormal heart atrium morphology	J:93157
	abnormal heart ventricle morphology	J:93157
	abnormal sinus venosus morphology	J:93157
	abnormal vascular branching morphogenesis	J:93157
	abnormal vascular development	J:93157
	abnormal vascular regression	J:93157
	abnormal vein morphology	J:93157
	abnormal vitelline vascular remodeling	J:93157
	embryonic growth retardation	J:93157
	embryonic lethality during organogenesis, complete penetrance	J:93157
	pericardial edema	J:93157
	trabecula carnea hypoplasia	J:93157
Dll4tm1Kaho/Dll4tm1Kaho Tg(Foxn1-cre)8Ghr/0 involves: C57BL/6 * DBA/2	abnormal lymphopoiesis	J:143473
	absent CD4-positive, alpha-beta T cells	J:143473
	absent CD8-positive, alpha-beta T cells	J:143473
	decreased double-positive T cell number	J:143473
	thymus hypoplasia	J:143473
Dll4tm1Nwg/Dll4+ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	abnormal artery development	J:94740
	abnormal blood vessel morphology	J:94740
	abnormal cardinal vein morphology	J:94740
	abnormal dorsal aorta morphology	J:94740
	abnormal induced retina neovascularization	J:177797
	abnormal internal carotid artery morphology	J:94740
	abnormal placenta vasculature	J:94740
	abnormal vascular development	J:94740
	abnormal vascular regression	J:94740
	abnormal vascular smooth muscle morphology	J:94740
	abnormal vein development	J:94740
	abnormal visceral yolk sac morphology	J:94740
	absent vitelline blood vessels	J:94740
	aorta stenosis	J:94740
	embryo tissue necrosis	J:94740
	embryonic lethality during organogenesis, incomplete penetrance	J:94740
Dll4tm1Nwg/Dll4+ involves: 129S6/SvEvTac * C57BL/6NTac * ICR	embryonic lethality during organogenesis, incomplete penetrance	J:94740
Dll4tm1Vlcg/Dll4tm1Vlcg Not Specified	no abnormal phenotype detected	J:177290
Dll4tm2.1Vlcg/Dll4+ Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac	abnormal induced retina neovascularization	J:177797
	abnormal vascular regression	J:177797
Dll4tm2.1Vlcg/Dll4+ Tg(Nanog-cre)#Vlcg/0 involves: 129S6/SvEvTac * C57BL/6NTac	abnormal angiogenesis	J:200671
	abnormal embryo development	J:200671
Dll4tm2.1Vlcg/Dll4tm2.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671
Dll4tm2.1Vlcg/Dll4tm2.1Vlcg Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * C57BL/6NTac	abnormal retina vasculature morphology	J:200671
Dll4tm3.1Vlcg/Dll4+ Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671