Irf3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irf3
interferon regulatory factor 3
MGI:1859179

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Irf3^tm1Ttg/Irf3^tm1Ttg B6.129-Irf3^tm1Ttg	abnormal retina outer nuclear layer morphology	J:281010
	abnormal retina outer plexiform layer morphology	J:281010
	decreased a-wave amplitude	J:281010
	decreased b-wave amplitude	J:281010
	decreased total retina thickness	J:281010
	retina degeneration	J:281010
	retina outer nuclear layer degeneration	J:281010
	thin retina outer nuclear layer	J:281010
	thin retina outer plexiform layer	J:281010
Irf3^tm1Ttg/Irf3^tm1Ttg involves: 129S/SvEv * C57BL/6	decreased cellular sensitivity to ultraviolet irradiation	J:150948
Irf3^tm1Ttg/Irf3^tm1Ttg involves: 129S/SvEv * C57BL/6J	abnormal circulating interferon level	J:98127
Irf3^tm1Ttg/Irf3^tm1Ttg involves: 129S/SvEv * C57BL/6J	increased susceptibility to Picornaviridae infection	J:98127
Irf3^tm1Ttg/Irf3^tm1Ttg Irf7^tm1Ttg/Irf7^tm1Ttg involves: 129P2/OlaHsd * 129S/SvEv	decreased interferon-beta secretion	J:158969
	decreased interleukin-1 beta secretion	J:158969
	increased susceptibility to bacterial infection	J:158969
	increased susceptibility to Herpesvirales infection	J:158969
	increased susceptibility to Paramyxoviridae infection	J:158969
Irf3^tm1Ttg/Irf3^tm1Ttg Irf9^tm1Ttg/Irf9^tm1Ttg involves: 129S/SvEv * C57BL/6J	abnormal cytokine secretion	J:98127
Irf3^tm1Ttg/Irf3^tm1Ttg Sting1^em1Jmin/Sting1^em1Jmin involves: 129S/SvEv * C57BL/6N	decreased single-positive T cell number	J:251372
	increased myeloid cell number	J:251372
	lung inflammation	J:251372

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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