Sec61a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sec61a1
SEC61 translocon subunit alpha 1
MGI:1858417

24 phenotypes from 1 allele in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Sec61a1^m1Gek/Sec61a1⁺ C57BL/6J-Sec61a1^m1Gek	decreased circulating insulin level	J:164159
Sec61a1^m1Gek/Sec61a1⁺ C57BL/6J-Sec61a1^m1Gek	hyperglycemia	J:164159
Sec61a1^m1Gek/Sec61a1^m1Gek C57BL/6J-Sec61a1^m1Gek	abnormal glucose homeostasis	J:164159
	abnormal pancreatic beta cell morphology	J:164159
	abnormal pancreatic beta cell physiology	J:164159
	abnormal pancreatic delta cell morphology	J:164159
	decreased body size	J:164159
	decreased circulating insulin level	J:164159
	decreased lean body mass	J:164159
	decreased pancreatic beta cell number	J:164159
	decreased skeletal muscle mass	J:164159
	decreased total body fat amount	J:164159
	enlarged liver	J:164159
	hepatic steatosis	J:164159
	hyperglycemia	J:164159
	impaired glucose tolerance	J:164159
	increased circulating cholesterol level	J:164159
	increased circulating glucagon level	J:164159
	increased circulating triglyceride level	J:164159
	increased hepatocyte apoptosis	J:164159
	increased hepatocyte proliferation	J:164159
	increased pancreatic alpha cell number	J:164159
	increased pancreatic beta cell apoptosis	J:164159
	increased pancreatic delta cell number	J:164159
	liver cirrhosis	J:164159
	pale liver	J:164159

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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