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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atoh7
atonal bHLH transcription factor 7
MGI:1355553
39 phenotypes from 8 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atoh7tm1(Neurod1)Whk/Atoh7tm2(Neurod4)Whk
involves: 129S6/SvEvTac * C57BL/6 		abnormal optic nerve morphology J:141248
increased retina apoptosis J:141248
increased retina photoreceptor cell number J:141248
optic nerve hypoplasia J:141248
normal vision/eye phenotype J:141248
Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
either: 129(Cg)-Atoh7tm1.1(Ascl1)Nlbr or B6.129S6(Cg)-Atoh7tm1.1(Ascl1)Nlbr or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N) 		abnormal Muller cell morphology J:203642
abnormal retina bipolar cell morphology J:203642
abnormal retina vasculature morphology J:203642
absent optic nerve J:203642
decreased retina ganglion cell number J:203642
decreased total retina thickness J:203642
increased retina cone cell number J:203642
Atoh7tm1.1Xmu/Atoh7tm1.1Xmu
involves: 129S6/SvEvTac * C57BL/6 		no abnormal phenotype detected J:151244
Atoh7tm1Gan/Atoh7tm1(Neurod1)Whk
involves: 129S6/SvEvTac * C57BL/6 		abnormal optic nerve morphology J:141248
decreased retina ganglion cell number J:141248
increased retina apoptosis J:141248
optic nerve hypoplasia J:141248
Atoh7tm1Gan/Atoh7tm1Gan
B6.Cg-Atoh7tm1Gan 		abnormal eye electrophysiology J:135827
abnormal Muller cell morphology J:135827
abnormal retina ganglion cell morphology J:135827
abnormal retina morphology J:135827
decreased retina ganglion cell number J:135827
increased retina apoptosis J:135827
optic nerve hypoplasia J:135827
Atoh7tm1Gan/Atoh7tm1Gan
involves: 129S/SvEv * C57BL/6J 		increased amacrine cell number J:67382
normal reproductive system phenotype J:67382
Atoh7tm1Gan/Atoh7tm1Gan
Not Specified 		abnormal retina cone bipolar cell morphology J:119663
absent optic nerve J:141248
absent retina ganglion cell J:141248
increased amacrine cell number J:119663
Atoh7tm1Gan/Atoh7tm2(Neurod4)Whk
involves: 129S6/SvEvTac * C57BL/6 		absent optic nerve J:141248
decreased retina ganglion cell number J:141248
Atoh7tm1Gan/Atoh7tm2Gan
involves: 129S/SvEv * C57BL/6J 		abnormal retina ganglion cell morphology J:67382
abnormal retina nerve fiber layer morphology J:67382
Atoh7tm1Gla/Atoh7tm1Gla
B6.129-Atoh7tm1Gla 		abnormal circardian behavior entrainment J:99410
abnormal eye electrophysiology J:99410
abnormal retina bipolar cell morphology J:99410
abnormal retina cone bipolar cell morphology J:99410
abnormal retina rod bipolar cell morphology J:99410
absent optic tract J:99410
decreased retina rod cell number J:99410
thin retina inner nuclear layer J:99410
thin retina inner plexiform layer J:99410
thin retina outer nuclear layer J:99410
thin retina outer plexiform layer J:99410
Atoh7tm1Gla/Atoh7tm1Gla
either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) 		abnormal cell cycle J:110600
abnormal eye development J:110600
abnormal retina cone cell morphology J:110600
Atoh7tm1Gla/Atoh7tm1Gla
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J 		abnormal blood vessel morphology J:70746
abnormal eye development J:70746
abnormal optic vesicle formation J:70746
abnormal retina morphology J:70746
abnormal retina vasculature morphology J:70746
absent optic nerve J:70746
absent retina ganglion layer J:70746
decreased total retina thickness J:70746
thin retina inner nuclear layer J:70746
thin retina inner plexiform layer J:70746
Atoh7tm1Gla/Atoh7tm1Gla
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal retina morphology J:186563
abnormal retina nerve fiber layer morphology J:186563
absent optic nerve J:186563
Atoh7tm1Gla/Atoh7tm1Gla
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1 		abnormal amacrine cell morphology J:70746
abnormal retina ganglion layer morphology J:70746
absent retina ganglion cell J:70746
increased retina cone cell number J:70746
Atoh7tm2Gan/Atoh7tm2Gan
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2 		decreased retina ganglion cell number J:167071
Atoh7tm2Gan/Atoh7tm2Gan
involves: 129S/SvEv * C57BL/6J 		abnormal optic nerve morphology J:67382
abnormal retina ganglion cell morphology J:67382
abnormal retina morphology J:67382
abnormal retina nerve fiber layer morphology J:67382
decreased optic chiasm size J:67382
decreased retina ganglion cell number J:67382
decreased total retina thickness J:67382
normal reproductive system phenotype J:67382
Atoh7tm2Gan/Atoh7tm2Gan
Not Specified 		abnormal rod electrophysiology J:194077
Atoh7tm3(cre)Gan/Atoh7tm3(cre)Gan
involves: 129S7/SvEvBrd * C57BL/6J 		decreased retina ganglion cell number J:86669, J:176668
normal vision/eye phenotype J:176668
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory