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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Prkn
parkin RBR E3 ubiquitin protein ligase
MGI:1355296
24 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Gpx1tm1Ysh/Gpx1tm1Ysh
Prkntm1Shn/Prkntm1Shn
Park7tm1Shn/Park7tm1Shn
B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn
impaired coordination J:202221
increased dopamine level J:202221
increased serotonin level J:202221
Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+
Prkntm1Roo/Prkntm1Roo
Slc6a3tm1(cre)Lrsn/Slc6a3+
Tfamtm1Lrsn/Tfamtm1Lrsn
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
abnormal axonal transport J:176022
abnormal neuron morphology J:176022
loss of dopaminergic neurons J:176022
Prkntm1Ccs/Prkntm1Ccs
Tg(CAG-SNCA*)1.1Ccs/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal cellular respiration J:127707
abnormal mitochondrial ATP synthesis coupled electron transport J:127707
abnormal mitochondrion morphology J:127707
abnormal neuron morphology J:127707
brain vacuoles J:127707
normal nervous system phenotype J:127707
Prkntm1Ccs/Prkntm1Ccs
Tg(Th-SNCA*)1.2Ccs/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal cellular respiration J:127707
abnormal mitochondrial ATP synthesis coupled electron transport J:127707
abnormal mitochondrion morphology J:127707
abnormal neuron morphology J:127707
brain vacuoles J:127707
normal nervous system phenotype J:127707
Prkntm1Shn/Prkntm1Shn
Park7tm1Shn/Park7tm1Shn
B6.Cg-Park7tm1Shn Prkntm1Shn
impaired coordination J:202221
increased serotonin level J:202221
Prkntm1Shn/Prkntm1Shn
Slc6a3tm4.1(tTA)Xz/?
Tg(tetO-SNCA*A53T)E2Cai/?
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
abnormal mitochondrion morphology J:218892
neuronal cytoplasmic inclusions J:218892
Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/0
involves: 129P2/OlaHsd * C57BL/6
normal behavior/neurological phenotype J:140326
neuron degeneration J:140326
Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
involves: 129P2/OlaHsd * C57BL/6
normal behavior/neurological phenotype J:140326
neuron degeneration J:140326
Prkntm1Ykt/Prkntm1Ykt
Tg(Prp-GPR37)1Ryot/0
involves: 129P2/OlaHsd * C3H * C57BL/6
abnormal redox activity J:140326
normal behavior/neurological phenotype J:140326
decreased dopamine level J:140326
decreased dopaminergic neuron number J:140326
increased dopamine level J:140326
neuron degeneration J:140326
oxidative stress J:140326
Prkntm1Ykt/Prkntm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
involves: 129P2/OlaHsd * C3H * C57BL/6
abnormal redox activity J:140326
normal behavior/neurological phenotype J:140326
decreased dopamine level J:140326
decreased dopaminergic neuron number J:140326
increased dopamine level J:140326
neuron degeneration J:140326
Tg(Slc6a3-PARK2*Q311X)AXwy/0
FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy
abnormal locomotor activation J:146833
abnormal substantia nigra morphology J:146833
abnormal touch/ nociception J:146833
decreased dopamine level J:146833
decreased vertical activity J:146833
hypoactivity J:146833
impaired balance J:146833
loss of dopaminergic neurons J:146833
Tg(Slc6a3-PARK2*Q311X)DXwy/0
FVB/NJ-Tg(Slc6a3-PARK2*Q311X)DXwy
abnormal touch/ nociception J:146833
normal behavior/neurological phenotype J:146833
hypoactivity J:146833
loss of dopaminergic neurons J:146833

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory