Tfr2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tfr2
transferrin receptor 2
MGI:1354956

27 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tfr2^{em1(IMPC)Rbrc}/Tfr2^{em1(IMPC)Rbrc} C57BL/6N-Tfr2^{em1(IMPC)Rbrc}/Rbrc	abnormal colon morphology	J:211773
	abnormal erythrocyte cell number	J:211773
	abnormal heart morphology	J:211773
	abnormal hemoglobin content	J:211773
	abnormal liver morphology	J:211773
	abnormal mean corpuscular hemoglobin	J:211773
	abnormal mean corpuscular hemoglobin concentration	J:211773
	abnormal mean corpuscular volume	J:211773
	abnormal rectum morphology	J:211773
	decreased erythrocyte cell number	J:211773
	enlarged heart	J:211773
	increased circulating iron level	J:211773
	increased hemoglobin content	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
	increased mean corpuscular volume	J:211773
Tfr2^m1Btlr/Tfr2^m1Btlr C57BL/6J-Tfr2^m1Btlr	abnormal iron homeostasis	J:148982
	increased circulating ferritin level	J:148982
	increased circulating iron level	J:148982
Tfr2^tm1.1Anro/Tfr2^tm1.1Anro 129.Cg-Tfr2^tm1.1Anro	decreased body weight	J:160785
	normal homeostasis/metabolism phenotype	J:160785
	increased cellular hemoglobin content	J:160785
	increased hemoglobin content	J:160785
	increased liver iron level	J:160785
	increased spleen iron level	J:160785
	macrocytic anemia	J:160785
Tfr2^tm1.1Nsub/Tfr2^tm1.1Nsub involves: 129T2/SvEms	increased circulating iron level	J:160785
	increased liver iron level	J:160785
	increased spleen iron level	J:160785
Tfr2^tm1.1Nsub/Tfr2^tm1.1Nsub involves: 129T2/SvEms * C57BL/6	decreased spleen iron level	J:114330
	hemochromatosis	J:114330
	increased circulating iron level	J:114330
	increased liver iron level	J:114330
Tfr2^tm1Slu/Tfr2^tm1Slu involves: 129X1/SvJ * C57BL/6J	abnormal iron homeostasis	J:78360
	decreased spleen iron level	J:78360
	normal hematopoietic system phenotype	J:78360
	increased circulating iron level	J:78360
	increased liver iron level	J:78360
Tg(Alb1-cre)7Gsc/0 Tfr2^tm1.1Anro/Tfr2^tm1.1Anro involves: 129/Sv * C57BL/6 * FVB/N	normal hematopoietic system phenotype	J:160785
	increased circulating iron level	J:160785
	increased liver iron level	J:160785

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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