E2f6 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

E2f6
E2F transcription factor 6
MGI:1354159

18 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Bmi1^tm1Brn/Bmi1⁺ E2f6^tm1Lees/E2f6⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	cervical vertebral transformation	J:134271
	lumbar vertebral transformation	J:134271
	thoracic vertebral transformation	J:134271
Bmi1^tm1Brn/Bmi1⁺ E2f6^tm1Lees/E2f6^tm1Lees involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	cervical vertebral transformation	J:134271
	lumbar vertebral transformation	J:134271
	thoracic vertebral transformation	J:134271
Bmi1^tm1Brn/Bmi1^tm1Brn E2f6^tm1Lees/E2f6⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal vertebrae morphology	J:134271
	cervical vertebral transformation	J:134271
	lumbar vertebral transformation	J:134271
	thoracic vertebral transformation	J:134271
Bmi1^tm1Brn/Bmi1^tm1Brn E2f6^tm1Lees/E2f6^tm1Lees involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal bone marrow cell morphology/development	J:134271
	abnormal cell cycle	J:134271
	abnormal vertebrae morphology	J:134271
	anemia	J:134271
	ataxia	J:134271
	cerebellum hypoplasia	J:134271
	cervical vertebral transformation	J:134271
	decreased bone marrow cell number	J:134271
	decreased cell proliferation	J:134271
	decreased double-positive T cell number	J:134271
	decreased hematopoietic cell number	J:134271
	early cellular replicative senescence	J:134271
	lumbar vertebral transformation	J:134271
	postnatal growth retardation	J:134271
	postnatal lethality, incomplete penetrance	J:134271
	premature death	J:134271
	prenatal lethality, incomplete penetrance	J:134271
	thoracic vertebral transformation	J:134271

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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