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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
MGI:1353576
27 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ace2tm1Pngr/Y
Pik3cgtm1Pngr/Pik3cgtm1Pngr
involves: 129P2/OlaHsd * C57BL/6 		increased cardiac muscle contractility J:124548
Apoetm1Unc/Apoetm1Unc
Pik3cgtm1Dwu/Pik3cgtm1Dwu
B6.Cg-Apoetm1Unc Pik3cgtm1Dwu 		atherosclerotic lesions J:121582
decreased circulating cholesterol level J:121582
Pik3cdtm1Jni/Pik3cdtm1Jni
Pik3cgtm1Pngr/Pik3cgtm1Pngr
involves: 129P2/OlaHsd * C57BL/6 		abnormal NK cell differentiation J:124330
decreased cytotoxic T cell cytolysis J:124330
decreased interferon-gamma secretion J:124330
decreased NK cell number J:124330
decreased T cell number J:124330
spleen hypoplasia J:124330
Pik3cdtm1Tnr/Pik3cdtm1Tnr
Pik3cgtm1Pngr/Pik3cgtm1Pngr
B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr 		decreased inflammatory response J:134324
decreased susceptibility to induced arthritis J:134324
impaired neutrophil chemotaxis J:134324
impaired neutrophil recruitment J:134324
Pik3cdtm1Tnr/Pik3cdtm1Tnr
Pik3cgtm1Pngr/Pik3cgtm1Pngr
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal T cell differentiation J:125791
abnormal T cell physiology J:125791
abnormal thymus lobule morphology J:125791
decreased CD4-positive, alpha-beta T cell number J:125791
decreased CD8-positive, alpha-beta T cell number J:125791
decreased double-positive T cell number J:125791
decreased lymphocyte cell number J:125791
decreased T cell number J:125791
small thymus J:125791
thymus hypoplasia J:125791
Pik3cgtm1Dwu/Pik3cgtm1Dwu
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 		abnormal CD8-positive, alpha-beta T cell physiology J:131923
abnormal response to infection J:131923
normal immune system phenotype J:131923
Pik3cgtm1Pngr/Pik3cgtm1Pngr
Ptentm2Mak/Ptentm2Mak
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * FVB 		cardiac hypertrophy J:79151
enlarged heart J:79151
increased cardiac muscle contractility J:79151
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory