Dtx1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dtx1
deltex 1, E3 ubiquitin ligase
MGI:1352744

31 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dtx1^em1(IMPC)H/Dtx1^em1(IMPC)H C57BL/6N-Dtx1^em1(IMPC)H/H	abnormal locomotor behavior	J:211773
	decreased exploration in new environment	J:211773
	decreased locomotor activity	J:211773
	decreased prepulse inhibition	J:211773
	increased circulating glucose level	J:211773
Dtx1^tm1.1Mzl/Dtx1^tm1.1Mzl Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal thymocyte activation	J:151605
	increased anti-double stranded DNA antibody level	J:151605
	increased anti-histone antibody level	J:151605
	increased autoantibody level	J:151605
	increased interleukin-2 secretion	J:151605
	increased T cell proliferation	J:151605
Dtx1^tm1.2Mzl/Dtx1^tm1.2Mzl B6.129-Dtx1^tm1.2Mzl	abnormal lymphocyte morphology	J:151605
	abnormal lymphocyte physiology	J:151605
	abnormal regulatory T cell physiology	J:151605
	abnormal T cell anergy	J:151605
	abnormal thymocyte activation	J:151605
	decreased marginal zone B cell number	J:151605
	decreased thymocyte apoptosis	J:151605
	decreased transforming growth factor beta level	J:151605
	glomerulonephritis	J:151605
	increased anti-double stranded DNA antibody level	J:151605
	increased anti-histone antibody level	J:151605
	increased B cell proliferation	J:151605
	increased interferon-gamma secretion	J:151605
	increased interleukin-2 secretion	J:151605
	increased interleukin-4 secretion	J:151605
	increased T cell proliferation	J:151605
	liver inflammation	J:151605
	lung inflammation	J:151605
	renal glomerular immunoglobulin deposits	J:151605
	spleen hyperplasia	J:151605
Dtx1^tm1Crey/Dtx1^tm1Crey involves: 129P2/OlaHsd	no abnormal phenotype detected	J:95986
Dtx1^tm1Mjb/Dtx1^tm1Mjb either: B6.129S6-Dtx1^tm1Mjb or (involves: 129S6/SvEvTac * C57BL/6)	normal immune system phenotype	J:114658
Tg(Cd4-Dtx1)1Mzl/? involves: C57BL/6	abnormal T cell activation	J:151605
	abnormal thymocyte activation	J:151605
	decreased interleukin-2 secretion	J:151605
	decreased T cell proliferation	J:151605

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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