Abcc8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abcc8
ATP-binding cassette, sub-family C member 8
MGI:1352629

10 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Abcc8^em1(IMPC)J/Abcc8^em1(IMPC)J C57BL/6NJ-Abcc8^em1(IMPC)J/Mmjax	impaired glucose tolerance	J:211773
	increased lean body mass	J:211773
Abcc8^tm1.1Fmas/Abcc8⁺ B6.129S2(Cg)-Abcc8^tm1.1Fmas	abnormal pancreatic beta cell morphology	J:208932
Abcc8^tm1.1Fmas/Abcc8^tm1.1Fmas B6.129S2(Cg)-Abcc8^tm1.1Fmas	abnormal pancreatic beta cell morphology	J:208932
	decreased circulating glucose level	J:208932
	decreased insulin secretion	J:208932
	normal homeostasis/metabolism phenotype	J:208932
	impaired glucose tolerance	J:208932
	increased circulating glucose level	J:208932
	increased insulin secretion	J:208932
Abcc8^tm1.1Mgn/Abcc8^tm1.1Mgn involves: 129X1/SvJ * C57BL/6	decreased insulin secretion	J:79352
	hypoglycemia	J:79352
	impaired glucose tolerance	J:79352
Abcc8^tm1Jbry/Abcc8^tm1Jbry involves: 129X1/SvJ	abnormal insulin secretion	J:179577
	decreased circulating glucose level	J:179577
	decreased insulin secretion	J:179577
	increased circulating glucose level	J:179577
Abcc8^tm1Jbry/Abcc8^tm1Jbry involves: 129X1/SvJ * C57BL/6	hypoglycemia	J:61356
Abcc8^tm1Jbry/Abcc8^tm1Jbry involves: 129X1/SvJ * C57BL/6	impaired glucose tolerance	J:61356

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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