Ndrg2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ndrg2
N-myc downstream regulated gene 2
MGI:1352498

25 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ndrg2^tm1.1Hori/Ndrg2^tm1.1Hori B6.129-Ndrg2^tm1.1Hori	abnormal astrocyte physiology	J:214686
	abnormal glial cell physiology	J:214686
	abnormal microglial cell chemotaxis	J:214686
	decreased astrocyte number	J:214686
	decreased inflammatory response	J:214686
	decreased interleukin-6 secretion	J:214686
	decreased neuron apoptosis	J:214686
	decreased susceptibility to injury	J:214686
Ndrg2^tm1.1Xzg/Ndrg2⁺ involves: 129S/SvEv * C57BL/6 * FVB/N	abnormal thoracic vertebrae morphology	J:187603
	lumbar vertebral transformation	J:187603
	sacral vertebral transformation	J:187603
	thoracic vertebral transformation	J:187603
Ndrg2^tm1.1Xzg/Ndrg2^tm1.1Xzg involves: 129S/SvEv * C57BL/6 * FVB/N	abnormal thoracic vertebrae morphology	J:187603
	normal embryo phenotype	J:187603
	lumbar vertebral transformation	J:187603
	sacral vertebral transformation	J:187603
	thoracic vertebral transformation	J:187603
Ndrg2^tm1Kmori/Ndrg2⁺ involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	decreased survivor rate	J:210264
	increased brain tumor incidence	J:210264
	increased fibroblast proliferation	J:210264
	increased gastrointestinal tumor incidence	J:210264
	increased hepatocellular carcinoma incidence	J:210264
	increased lung carcinoma incidence	J:210264
	increased pancreas tumor incidence	J:210264
	increased skin tumor incidence	J:210264
	increased T cell derived lymphoma incidence	J:210264
	increased testis tumor incidence	J:210264
	increased tumor incidence	J:210264
	premature death	J:210264
Ndrg2^tm1Kmori/Ndrg2^tm1Kmori involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	decreased survivor rate	J:210264
	increased fibroblast proliferation	J:210264
	increased hepatocellular carcinoma incidence	J:210264
	increased lung carcinoma incidence	J:210264
	increased T cell derived lymphoma incidence	J:210264
	increased tumor incidence	J:210264
	premature death	J:210264
Ndrg2^tm1Xzg/Ndrg2^tm1Xzg Tg(Col1a1-cre)1Bek/0 involves: 129S/SvEv * CD-1	abnormal thoracic vertebrae morphology	J:187603
	lumbar vertebral transformation	J:187603
	sacral vertebral transformation	J:187603
	thoracic vertebral transformation	J:187603
Ndrg2^tm1Xzg/Ndrg2^tm1Xzg Tg(Col2a1-cre)1Bhr/0 involves: 129S/SvEv * C57BL/6 * SJL	abnormal thoracic vertebrae morphology	J:187603
	lumbar vertebral transformation	J:187603
	sacral vertebral transformation	J:187603
	thoracic vertebral transformation	J:187603

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23